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Titolo:
Hepatocellular carcinoma in HIV-infected patients with chronic hepatitis C
Autore:
Garcia-Samaniego, J; Rodriguez, M; Berenguer, J; Rodriguez-Rosado, R; Carbo, J; Asensi, V; Soriano, V;
Indirizzi:
Inst Salud Carlos III, Hosp Carlos III, Serv Hepatol, Madrid, Spain Inst Salud Carlos III Madrid Spain los III, Serv Hepatol, Madrid, Spain Inst Salud Carlos III, Hosp Carlos III, Infect Dis Serv, Madrid, Spain Inst Salud Carlos III Madrid Spain III, Infect Dis Serv, Madrid, Spain Univ Oviedo, Hosp Cent Asturias, Serv Gastroenterol, E-33080 Oviedo, SpainUniv Oviedo Oviedo Spain E-33080 rv Gastroenterol, E-33080 Oviedo, Spain Hosp Gen Gregorio Maranon, Infect Dis Serv, Madrid, Spain Hosp Gen Gregorio Maranon Madrid Spain , Infect Dis Serv, Madrid, Spain
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 1, volume: 96, anno: 2001,
pagine: 179 - 183
SICI:
0002-9270(200101)96:1<179:HCIHPW>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; LIVER FIBROSIS PROGRESSION; INTERFERON-ALPHA; NATURAL-HISTORY; DRUG-USERS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Samaniego, J C Valle de Enmedio 125, Madrid 28035, Spain C Valle de Enmedio 125 Madrid Spain 28035 035, Spain
Citazione:
J. Garcia-Samaniego et al., "Hepatocellular carcinoma in HIV-infected patients with chronic hepatitis C", AM J GASTRO, 96(1), 2001, pp. 179-183

Abstract

OBJECTIVES: Chronic hepatitis C is frequently seen in HIV-positive subjects infected through needle sharing or transfusion of contaminated blood products. Progression to end-stage liver disease seems to occur faster in thesepatients. As the life expectancy of HIV-infected persons has dramatically improved since the introduction of highly active antiretroviral therapies, cirrhosis and eventually hepatocellular carcinoma (HCC) may be recognized at an increasing rate in patients coinfected with HIV and hepatitis C virus (HCV). METHODS: We identified the main features of HIV-infected individuals with end-stage liver disease due to HCV infection and diagnosed with HCC in three HIV/AIDS referral centers, and compared these features to those of a control group of patients with HCV-related HCC but without HIV infection. RESULTS: Seven HIV-infected patients were identified. Of these, six were <45 yr of age and had been intravenous drug users. The mean time between exposure to HCV and the development of HCC was estimated to be 17.8 yr. Two subjects were coinfectcd with hepatitis B and delta viruses, respectively. Only one individual had been diagnosed of an AIDS-defining condition before the diagnosis of HCC was made. However, all subjects had <500 CD4+ T cells at the time of HCC diagnosis. Five died within the first 4 months of follow-up. Patients in the control group (n = 31) were significantly older (68.9 +/- 8.9 vs 42.2 +/- 10.4; p < 0.001) and the duration of HCV infection was significantly longer (28.1 +/- 10.9 vs 17.8 +/- 2.7; p < 0.05) than in thosewith HIV-HCV coinfection. CONCLUSIONS: HCC seems to occur at a younger age and after a shorter period of HCV infection in subjects coinfected with HIV. Thus, treatment of CHC should be encouraged in HIV-positive patients, and in those with HCV-related cirrhosis the periodic monitoring of alpha -fetoprotein and abdominal ultrasonography should be recommended. (Am J Gastroenterol 2001;96:179-183. (C) 2001 by Am. Coll. of Gastroenterology).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:19:01