Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of repeated exposure to alcohol on the response of the hypothalamic-pituitary-adrenal axis of the rat: I. Role of changes in hypothalamic neuronal activity
Autore:
Lee, S; Schmidt, ED; Tilders, FJH; Rivier, C;
Indirizzi:
Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Biol, La Jolla, CA 92037 USA Vrije Univ Amsterdam, Fac Med, Dept Pharmacol, Res Inst Neurosci,Grad Sch Neurosci Amsterdam, Amsterdam, Netherlands Vrije Univ Amsterdam AmsterdamNetherlands rdam, Amsterdam, Netherlands
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 1, volume: 25, anno: 2001,
pagine: 98 - 105
SICI:
0145-6008(200101)25:1<98:EORETA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; MESSENGER-RIBONUCLEIC-ACID; CENTRAL AMYGDALOID NUCLEUS; IMPAIRED STRESS-RESPONSE; PARAVENTRICULAR NUCLEUS; NITRIC-OXIDE; C-FOS; HORMONE CRH; ADRENOCORTICOTROPIN SECRETION; NEUROSECRETORY NEURONS;
Keywords:
adrenocorticotropin hormone; paraventricular nucleus; hypothalamic-pituitary-adrenal axis; alcohol; corticotropin-releasing factor; vasopressin; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rivier, C Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
S. Lee et al., "Effect of repeated exposure to alcohol on the response of the hypothalamic-pituitary-adrenal axis of the rat: I. Role of changes in hypothalamic neuronal activity", ALC CLIN EX, 25(1), 2001, pp. 98-105

Abstract

Background: Prior (3-12 days) injection of alcohol significantly blunts the response of the hypothalamic-pituitary-adrenal (HPA) axis to a second drug challenge without measurably altering responses to other stressors. We therefore determined whether adaptation in hypothalamic neurons underlies this decreased activity. Methods: Adult male rats were administered alcohol (4.5 g/kg intragastrically) or vehicle daily for three consecutive days and then were challenged with the vehicle or alcohol 7 days later. Levels of adrenocorticotropin hormone (ACTH) in the circulation, corticotropin-releasing factor (CRF), CRF receptors type 1 (CRFR1) and vasopressin (VP) transcripts in the paraventricular nucleus (PVN) of the hypothalamus, and CRF/VP peptide in the median eminence were measured. Results: Resting PVN levels of CRF, CRFR1, and VP were comparable in all animals on day 7 of recovery, whereas CRF and VP stores in the external zoneof the median eminence were decreased in animals previously exposed to alcohol. After the acute alcohol challenge on day 7, rats previously exposed to the drug exhibited a significant (p < 0.01) dampening of their PVN CRF and CRFR1, but not VP neuronal response, compared with vehicle-pretreated rats. Conclusion: Blunted neuronal activity of PVN CRF neurons may be responsible for the decreased ACTH response that we previously reported in rats that had been injected with alcohol several days earlier. In addition, and despite comparable PVN VP transcript levels, the lower levels of this peptide inthe median eminence also may participate in the blunted ACTH response thatwe observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:45:54