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Titolo:
Cystectomy for severe hemorrhagic cystitis in allogeneic stem cell transplant recipients
Autore:
Garderet, L; Bittencourt, H; Sebe, P; Kaliski, A; Claisse, JP; Esperou, H; Ribaud, P; Estrade, V; Gluckman, E; Gattegno, B;
Indirizzi:
Hop St Louis, Dept Bone Marrow Transplantat, Paris, France Hop St Louis Paris France Dept Bone Marrow Transplantat, Paris, France Tenon Hosp, AP HP, Dept Urol, Paris, France Tenon Hosp Paris FranceTenon Hosp, AP HP, Dept Urol, Paris, France
Titolo Testata:
TRANSPLANTATION
fascicolo: 12, volume: 70, anno: 2000,
pagine: 1807 - 1811
SICI:
0041-1337(200012)70:12<1807:CFSHCI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; RISK-FACTORS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Garderet, L Hop St Antoine, Dept Hematol, 184 Rue Faubourg St Antoine, F-75571 Paris 12, France Hop St Antoine 184 Rue Faubourg St Antoine Paris France 12 ce
Citazione:
L. Garderet et al., "Cystectomy for severe hemorrhagic cystitis in allogeneic stem cell transplant recipients", TRANSPLANT, 70(12), 2000, pp. 1807-1811

Abstract

Background. Hemorrhagic cystitis (HC) is a common complication following allogeneic stem cell transplantation (SCT). In rare cases, it can be severe,inducing kidney failure and sepsis, and become life-threatening. Methods. We report three cases of severe HC in stem cell transplant recipients. Risk factors and the management of these patients were studied, as well as severe HC cases reported in the literature. Results. All three patients received high-dose cyclophosphamide in addition to total body irradiation or busulfan in their preparative regimen. They underwent allogeneic SCT, one of them from unrelated cord blood. BK viruriawas detected in two cases at the onset of hematuria, HC lasted for more than 3 months, resulting in urinary tract obstruction and sepsis, Ultimately,cystectomy was the last therapeutic procedure available to treat this life-threatening complication. Conclusion. We describe three patients, among a total of more than 1300 patients treated in our unit by allogeneic bone marrow transplantation, in whom HC was severe and long lasting enough to require cystectomy as a life-saving procedure.

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Documento generato il 13/07/20 alle ore 19:35:32