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Titolo:
Iris melanoma in a patient with neurofibromatosis
Autore:
Honavar, SG; Singh, AD; Shields, CL; Shields, JA; Eagle, RC;
Indirizzi:
Thomas Jefferson Univ, Wills Eye Hosp, Oncol Serv, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Thomas Jefferson Univ, Wills Eye Hosp, Dept Pathol, Philadelphia, PA 19107USA Thomas Jefferson Univ Philadelphia PA USA 19107 Philadelphia, PA 19107USA
Titolo Testata:
SURVEY OF OPHTHALMOLOGY
fascicolo: 3, volume: 45, anno: 2000,
pagine: 231 - 236
SICI:
0039-6257(200011/12)45:3<231:IMIAPW>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVEAL MALIGNANT-MELANOMA; VONRECKLINGHAUSEN NEUROFIBROMATOSIS; CHOROIDAL MELANOMA; INTRAOCULAR TUMORS; TYPE-1;
Keywords:
enucleation; glaucoma; iris; Lisch nodule; melanoma; neurofibromatosis type 1; von Recklinghausen's disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, AD Thomas Jefferson Univ, Wills Eye Hosp, Oncol Serv, 900 Walnut St, Philadelphia, PA 19107 USA Thomas Jefferson Univ 900 Walnut St Philadelphia PA USA 19107 SA
Citazione:
S.G. Honavar et al., "Iris melanoma in a patient with neurofibromatosis", SURV OPHTHA, 45(3), 2000, pp. 231-236

Abstract

Neurofibromatosis type 1 (NF1) is a common autosomal dominant hamartomatous disorder, which is considered to be a neurocristopathy. Uveal melanoma, also of neural crest origin, is the most common primary malignant intraocular tumor in adults. The association of NF1 and uveal melanoma is controversial. We present a clinicopathologic report of iris melanoma in a patient with NF1 and review the literature for a possible causal association. To our knowledge, only 18 cases of uveal melanoma, including three cases of iris melanoma, have been reported in association with NF1. On the basis of the prevalence of NF1 (1 in 3000) and the prevalence of uveal melanoma (1 in 13,500), it can be estimated that approximately seven patients with NF1 in the United States would have an associated uveal melanoma by chance alone. We conclude that despite the theoretical possibility of a causal association of uveal melanoma and NF1, it may still be regarded as coincidental in the absence of any strong evidence to the contrary. (Surv Ophthalmol 45:231-236, 2000. (C) 2000 by Elsevier Science Inc. All rights reserved.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:07:30