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Titolo:
Role of neutrophils in burn-induced microvascular injury in the intestine
Autore:
Sir, O; Fazal, N; Choudhry, MA; Goris, RJA; Gamelli, RL; Sayeed, MM;
Indirizzi:
Loyola Univ, Med Ctr, Burn & Shock Trauma Inst, Trauma & Crit Care Res Lab, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Crit Care Res Lab, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Dept Surg, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 ed Ctr, Dept Surg, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Dept Physiol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Ctr, Dept Physiol, Maywood, IL 60153 USA Univ Nijmegen Hosp, Dept Surg, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands
Titolo Testata:
SHOCK
fascicolo: 2, volume: 14, anno: 2000,
pagine: 113 - 117
SICI:
1073-2322(200008)14:2<113:RONIBM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERMAL-INJURY; INFLAMMATORY RESPONSE; MONOCLONAL-ANTIBODY; REPERFUSION INJURY; RAT; LUNG; ACCUMULATION; MEDIATORS; DEPLETION; LEAKAGE;
Keywords:
rat; ileum; jejunum; endothelium; albumin permeability; edema; antineutrophil antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sayeed, MM Loyola Univ, Med Ctr, Burn & Shock Trauma Inst, Trauma & Crit Care Res Lab, 2160 S 1st Ave, Maywood, IL 60153 USA Loyola Univ 2160 S 1st Ave Maywood IL USA 60153 d, IL 60153 USA
Citazione:
O. Sir et al., "Role of neutrophils in burn-induced microvascular injury in the intestine", SHOCK, 14(2), 2000, pp. 113-117

Abstract

The present study evaluated burn-induced vascular permeability alterationsof rat small intestine in vivo and assessed the effect of neutrophil depletion in burn-injured rats on the altered intestinal microvascular permeability. I-125-labeled bovine serum albumin (I-125-BSA) was injected intravenously, and its leakage from circulation into the intestinal tissue was determined by measuring tissue counts of I-125-BSA. Compared with sham, vascular albumin permeability increased 1.7-fold on day 1 post-burn and 3.0-fold on day 3 post-burn in ileum. In the jejunum, albumin permeability increased 1.8- and 2.5-fold on day 1 and day 3 post-burn, respectively. Intestinal tissue edema, determined as increases in tissue water contents, was noted in both intestinal segments on day 1 post-burn; no further increase in edema wasfound on day 3 post-burn. Neutrophil depletion before burn injury prevented the vascular leakage of albumin and edema in the ileum and jejunum on day1 post-burn. On day 3 post-burn, the effect of prior neutrophil depletion on vascular permeability was less marked, and edema formation was not affected at all. These findings indicate that an absence of neutrophils preventsthe loss of intestinal vascular barrier properties only in the initial periods after burns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:20:57