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Titolo:
Angiotensin II blockade in existing hypovolemia: Effects of candesartan inthe porcine splanchnic and renal circulation
Autore:
Laesser, M; Fandriks, L; Pettersson, A; Ewert, S; Aneman, A;
Indirizzi:
Univ Gothenburg, Dept Physiol, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden urg, Dept Physiol, Gothenburg, Sweden Univ Gothenburg, Dept Pharmacol, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden g, Dept Pharmacol, Gothenburg, Sweden Univ Gothenburg, Ctr Gastroenterol Res, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden Gastroenterol Res, Gothenburg, Sweden Univ Gothenburg, Dept Clin Pharmacol, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden pt Clin Pharmacol, Gothenburg, Sweden Univ Gothenburg, Dept Anesthesiol & Intens Care, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden iol & Intens Care, Gothenburg, Sweden
Titolo Testata:
SHOCK
fascicolo: 4, volume: 14, anno: 2000,
pagine: 471 - 477
SICI:
1073-2322(200010)14:4<471:AIBIEH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER FLOWMETRY; MUCOSAL BLOOD-FLOW; CARDIOGENIC-SHOCK; CONVERTING ENZYME; PERFUSION; HEMORRHAGE; ISCHEMIA; PIGS; RAT; RESUSCITATION;
Keywords:
hemorrhage; gastrointestinal; kidney; circulation; renin-angiotensin system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Aneman, A Sahlgrens Univ Hosp, Dept Anesthesiol & Intens Care, S-41385 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41385 thenburg, Sweden
Citazione:
M. Laesser et al., "Angiotensin II blockade in existing hypovolemia: Effects of candesartan inthe porcine splanchnic and renal circulation", SHOCK, 14(4), 2000, pp. 471-477

Abstract

Angiotensin II (AngII) is an important vasoconstrictor during hypovolemia. This study focused on the effects of the AngII receptor blocker candesartan on intestinal, hepatic, and renal hemodynamics during severe hypovolemia when administered in preexisting moderate hypovolemia, It was hypothesized that specific AngII receptor blockade might enhance splanchnic perfusion during hypovolemia. Fasted, anesthetized, ventilated, juvenile pigs were hemorrhaged by 20% of the blood volume for 30 min. Animals were then randomizedto receive candesartan (CAND, n = 11) or the vehicle (CTRL, n = 10) prior to further hemorrhage to 40% of the blood volume for 30 min. The shed bloodwas then retransfused. Systemic and splanchnic hemodynamics were recorded including intestinal mucosal, superficial and parenchymal hepatic, and cortical and medullary renal microcirculation by laser-Doppler flowmetry. Arterial blood gases were analysed. Candesartan-treated animals maintained mesenteric and jejunal mucosal perfusion during 40% hypovolemia compared to CTRLanimals, while no differences were observed in the hepatic and renal circulation. Retransfusion restored mesenteric and renal blood flows despite persistent hypotension and reduced cardiac output in both CAND and CTRL animals. Renal medullary and hepatic parenchymal microcirculation failed to recover during retransfusion in both CAND and CTRL animals. Arterial acidosis, hypercarbia, and a negative base excess were observed in CTRL animals following retransfusion whereas those parameters were normalised in CAND animals. Administration of candesartan in moderate hypovolemia ameliorated the reduction and consequences of mesenteric and intestinal, but not hepatic perfusion during severe hypovolemia. No adverse effects were observed in the renal circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:21:50