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Titolo:
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
Autore:
Nishimura, H; Okazaki, T; Tanaka, Y; Nakatani, K; Hara, M; Matsumori, A; Sasayama, S; Mizoguchi, A; Hiai, H; Minato, N; Honjo, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med Chem, Sakyo Ku, Kyoto 6068501, Japan Osaka City Univ, Sch Med, Dept Anat 2, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 d, Dept Anat 2, Osaka 5458585, Japan Kyoto Univ, Grad Sch Med, Dept Immunol & Cell Biol, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Cell Biol, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 ovasc Med, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Grad Sch Med, Dept Anat & Neurobiol, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Neurobiol, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Grad Sch Med, Dept Pathol & Biol Dis, Sakyo Ku, Kyoto 6068501,Japan Kyoto Univ Kyoto Japan 6068501 & Biol Dis, Sakyo Ku, Kyoto 6068501,Japan
Titolo Testata:
SCIENCE
fascicolo: 5502, volume: 291, anno: 2001,
pagine: 319 - 322
SICI:
0036-8075(20010112)291:5502<319:ADCIPR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODIES; DISEASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Honjo, T Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Yoshida Konoe Cho, Kyoto 6068501, Japan Kyoto Univ Yoshida Konoe Cho Kyoto Japan 6068501 6068501, Japan
Citazione:
H. Nishimura et al., "Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice", SCIENCE, 291(5502), 2001, pp. 319-322

Abstract

Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mice, but not in BALB/c RAG-2(-/-) mice, causeddilated cardiomyopathy with severely impaired contraction and sudden deathby congestive heart failure. Affected hearts showed diffuse deposition of immunoglobulin G (IgG) on the surface of cardiomyocytes. ALL of the affected PD-1(-/-) mice exhibited high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes. These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:21:28