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Titolo:
Behavioral, neurochemical, and brain morphology features of the 101/HY mice: A genetic model of some human hereditary diseases
Autore:
Lilp, IG; Bizikoeva, FZ; Revishin, AV; Korochkin, LI; Ivanov, VI; Poletaeva, II;
Indirizzi:
Russian Acad Med Sci, Med Genet Res Ctr, Inst Human Genet, Moscow 115478, Russia Russian Acad Med Sci Moscow Russia 115478 n Genet, Moscow 115478, Russia Russian Acad Sci, Severtsov Inst Ecol & Evolut, Moscow 117071, Russia Russian Acad Sci Moscow Russia 117071 ol & Evolut, Moscow 117071, Russia Russian Acad Sci, Inst Gene Biol, Moscow 117334, Russia Russian Acad Sci Moscow Russia 117334 t Gene Biol, Moscow 117334, Russia Moscow MV Lomonosov State Univ, Dept Higher Nervous Act, Fac Biol, Moscow 119899, Russia Moscow MV Lomonosov State Univ Moscow Russia 119899 oscow 119899, Russia
Titolo Testata:
RUSSIAN JOURNAL OF GENETICS
fascicolo: 12, volume: 36, anno: 2000,
pagine: 1344 - 1356
SICI:
1022-7954(200012)36:12<1344:BNABMF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR COLLICULUS PLAYS; AUDIOGENIC-SEIZURES; LABORATORY MICE; MOUSE STRAINS; MUTANT MOUSE; DNA-REPAIR; THIO-TEPA; SUSCEPTIBILITY; ABNORMALITIES; INSTABILITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Lilp, IG Russian Acad Med Sci, Med Genet Res Ctr, Inst Human Genet, Moscow115478, Russia Russian Acad Med Sci Moscow Russia 115478 Moscow 115478, Russia
Citazione:
I.G. Lilp et al., "Behavioral, neurochemical, and brain morphology features of the 101/HY mice: A genetic model of some human hereditary diseases", RUSS J GEN, 36(12), 2000, pp. 1344-1356

Abstract

Studies of behavior, neurophysiological reactions, neuromediator synthesisand brain structure of mice of the 101/HY strain (including those of the authors) are reviewed. This mouse strain is characterized by a chromosomal instability because of a recessive mutation mutator-1(mut-1) and the defective DNA excision repair. Experimental studies revealed a number of behavioral and neurological deviations in the 101/HY as compared to the CBA and the C3H mouse strains. These are abnormalities in spatial orientation, altered fear and anxiety reactions, anomalous locomotion, seizure developing in response to agents of various nature, and disturbances of the central nervous system, both structural and biochemical. Genome instability results in a number of neurological mutations, that may lead to the phenotypical effects observed in the 101/HY mice. Since the 101/HY mice partially display signs of severe human hereditary diseases caused by chromosomal instability and defective DNA repair, they can serve as a promising genetic model for these and other diseases related to impairment of the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:09:49