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Titolo:
QUANTITATIVE ASSESSMENT OF IGG AND IGA SUBCLASS PRODUCING CELLS IN RECTAL MUCOSA DURING SHIGELLOSIS
Autore:
ISLAM D; VERESS B; BARDHAN PK; LINDBERG AA; CHRISTENSSON B;
Indirizzi:
INT CTR DIARRHOEAL DIS RES,DIV SCI LAB,GPO BOX 128 DHAKA 1000 BANGLADESH KAROLINSKA INST,HUDDINGE UNIV HOSP,DIV PATHOL S-10401 STOCKHOLM SWEDEN INT CTR DIARRHOEAL DIS RES,DIV CLIN SCI DHAKA 1000 BANGLADESH KAROLINSKA INST,HUDDINGE UNIV HOSP,DIV CLIN IMMUNOL S-10401 STOCKHOLMSWEDEN KAROLINSKA INST,HUDDINGE UNIV HOSP,DIV PATHOL S-10401 STOCKHOLM SWEDEN PASTEUR MERIEUX,CONNAUGHT GRP MARCY LETOILE FRANCE
Titolo Testata:
Journal of Clinical Pathology
fascicolo: 6, volume: 50, anno: 1997,
pagine: 513 - 520
SICI:
0021-9746(1997)50:6<513:QAOIAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-PRODUCING CELLS; SECRETORY COMPONENT; ULCERATIVE-COLITIS; IMMUNOHISTOCHEMICAL EVALUATION; RESTORATIVE PROCTOCOLECTOMY; CARCINOEMBRYONIC ANTIGEN; INTERFERON-GAMMA; ILEAL RESERVOIR; CROHNS-DISEASE; EPITHELIAL IGA;
Keywords:
SHIGELLOSIS; DEGREE OF INFLAMMATION; IMMUNOGLOBULIN PRODUCING CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D. Islam et al., "QUANTITATIVE ASSESSMENT OF IGG AND IGA SUBCLASS PRODUCING CELLS IN RECTAL MUCOSA DURING SHIGELLOSIS", Journal of Clinical Pathology, 50(6), 1997, pp. 513-520

Abstract

Aims-To assess quantitatively both the morphological changes in the rectal mucosa and the changes in the relative frequency of IgA and IgG subclass producing cells found in the rectal mucosa during the acute phase of shigellosis and at convalescence. Methods-Rectal biopsies from25 Shigella dysenteriae 1 infected patients, 10 Shigella flexneri infected patients, and 40 uninfected controls were studied. Morphologicalchanges in the mucosa were graded. The frequency of IgA and IgG subclass producing cells was assessed. In addition, immunostaining for secretory component in epithelial cells was analysed. Results-Using morphological grading, 20% of the 35 patients studied had advanced inflammation (grade 3) in the acute phase of the disease. At convalescence, grade 1 inflammation was seen in 37% of the patients and in 10% of the controls. In the acute phase, as well as at convalescence, the number ofIgA(1), IgA(2), and IgG(2) positive cells was significantly higher than in the controls. The results were related to the histopathological degree of inflammation. Conclusions-In shigellosis, there is evidence for a prolonged humoral response residing in the mucosa long after theclinical symptoms have resolved, suggesting that shigellosis induces persisting mucosal humoral immune and inflammatory responses, remaining at least until 30 days after the infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:27:19