Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice
Autore:
Nakanishi, K; Gattone, VH; Sweeney, WE; Avner, ED;
Indirizzi:
Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 l Biol, Indianapolis, IN 46202 USA Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA Rainbow Babies & Childrens Hosp Cleveland OH USA 44106 land, OH 44106 USA Case Western Reserve Univ, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 45 - 50
SICI:
0931-041X(200101)16:1<45:RDBNCC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC KIDNEY-DISEASE; FACTOR GENE-EXPRESSION; MESSENGER-RNA; FACTOR-ALPHA; MOUSE; RAT; DIFFERENTIATION; MODEL; GLAND;
Keywords:
epidermal growth factor; polycystic; kidney; liver; ARPKD; mice; bpk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Gattone, VH Indiana Univ, Sch Med, Dept Anat & Cell Biol, 635 Barnhill Dr,Indianapolis, IN 46202 USA Indiana Univ 635 Barnhill Dr Indianapolis IN USA 46202 202 USA
Citazione:
K. Nakanishi et al., "Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice", PED NEPHROL, 16(1), 2001, pp. 45-50

Abstract

BALB/c mice homozygous for the bpk gene exhibit a form of autosomal recessive (AR) polycystic kidney disease (PKD) with massive collecting duct cysts, common bile duct dilation and chaotic intrahepatic bile ducts/portal triads. The combined renal and biliary pathology mimics much of the pathology seen in human ARPKD. Murine models of ARPKD generally have a reduced renal expression of epidermal growth factor (EGF) and an increased expression of EGF receptors (EGF-R). However, the role that EGF and EGF-R play in the progression of PKD has been unclear. Evidence from various model systems/ages of treatment produces conflicting results. Treating neonatal C57BL/6J-cpk mice with EGF ameliorates the renal pathology and dysfunction while treating 2- and 3-week-old bpk mice with an EGF-receptor tyrosine kinase inhibitor also ameliorates ARPKD. Therefore, to determine whether neonatal EGF treatment would accelerate or inhibit the progression of the PKD in bpk mice, we administered exogenous EGF (1 mug/g body weight subcutaneously) daily from postnatal days 3-9 (a critical period for tubule maturation). Neonatal EGF treatment but not sham treatment retarded the development of azotemia and common bile duct dilation and the chaotic hepatic triad changes in cystic mice. However, EGF treatment neither reduced the severity of the renal cystic pathology nor reduced the degree of cystic enlargement of the kidneys. Cystic mice treated past 9 days of age died prior to their scheduled termination at 21 days of age. The role of EGF in the progression of polycystic kidney disease in bpk mice is relatively complicated, with neonatal treatment being associated with some amelioration of the renal dysfunction and extrarenal pathology without an effect on the renal pathology. Continuation of treatment beyond 9 days increased morbidity. Therefore, in discussing the role of EGF or EGF receptor in mediating the pathophysiology of PKD, the stage of development may be an important consideration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:31:18