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Titolo:
A novel role for IRF-1 as a suppressor of apoptosis
Autore:
Chapman, RS; Duff, EK; Lourenco, PC; Tonner, E; Flint, DJ; Clarke, AR; Watson, CJ;
Indirizzi:
Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England Univ Edinburgh, Sch Med, Dept Pathol, Canc Res Campaign Labs, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland Hannah Res Inst, Ayr KA6 5HL, Scotland Hannah Res Inst Ayr Scotland KA6 5HL nah Res Inst, Ayr KA6 5HL, Scotland Univ Wales Coll Cardiff, Sch Biosci, Cardiff CF10 3US, S Glam, Wales Univ Wales Coll Cardiff Cardiff S Glam Wales CF10 3US 3US, S Glam, Wales
Titolo Testata:
ONCOGENE
fascicolo: 54, volume: 19, anno: 2000,
pagine: 6386 - 6391
SICI:
0950-9232(200012)19:54<6386:ANRFIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY-GLAND INVOLUTION; TRANSCRIPTION FACTOR IRF-1; CELL-DEATH; MICE; ACTIVATION; PATHWAYS; PROTEINS; BINDING; TISSUE;
Keywords:
IRF-1; apoptosis; mammary gland; involution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Watson, CJ Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB2 1QP, England Univ Cambridge Tennis Court Rd Cambridge England CB2 1QP gland
Citazione:
R.S. Chapman et al., "A novel role for IRF-1 as a suppressor of apoptosis", ONCOGENE, 19(54), 2000, pp. 6386-6391

Abstract

The tumour suppressor IRF-1 is a transcription factor involved in the induction of apoptosis in several in vitro systems, Post-lactational involutionof the mammary gland is characterized by extensive apoptosis of the epithelial cells, We have previously shown that signal transducer and activator of transcription (Stat) 3 drives apoptosis and involution in the mouse mammary gland, Since one of the downstream targets of the Stat signalling pathway is IRF-1, we have used IRF-1 knockout mice to address the potential role of this transcription factor in involution, Surprisingly, in the absence ofIRF-1 significantly higher numbers of apoptotic cells were found in involuting glands at 48 h compared to control glands, In addition, the alveolar structure in IRF-1 null mammary glands had collapsed whereas in control glands the alveoli remained intact and distended. However, by 72 h control and null glands were morphologically similar suggesting that IRF-1 suppresses apoptosis only during the early, reversible, stage of involution, This suggests a survival role for IRF-1 in mammary epithelia and demonstrates a novelrole for IRF-1 in vivo - suppression of premature epithelial apoptosis during mammary gland involution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:55:19