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Titolo:
The effect of urine volume and nitric oxide on basal bladder blood flow: Response to catheterization and drainage
Autore:
Lieb, J; Kogan, B; Das, AK; Leggett, RE; Schroder, A; Levin, RM;
Indirizzi:
Albany Coll Pharm, Div Basic & Pharmaceut Sci, Albany, NY 12208 USA AlbanyColl Pharm Albany NY USA 12208 harmaceut Sci, Albany, NY 12208 USA Albany Med Coll, Div Urol, Albany, NY 12208 USA Albany Med Coll Albany NYUSA 12208 Coll, Div Urol, Albany, NY 12208 USA Stratton Vet Adm Med Ctr, Albany, NY USA Stratton Vet Adm Med Ctr Albany NY USA n Vet Adm Med Ctr, Albany, NY USA Univ Mainz, Sch Med, Dept Urol, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 ch Med, Dept Urol, D-6500 Mainz, Germany
Titolo Testata:
NEUROUROLOGY AND URODYNAMICS
fascicolo: 1, volume: 20, anno: 2001,
pagine: 115 - 124
SICI:
0733-2467(2001)20:1<115:TEOUVA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELAXING FACTOR; INTERSTITIAL CYSTITIS; OUTLET OBSTRUCTION; ENDOTHELIAL-CELLS; VASCULAR TONE; L-ARGININE; RELAXATION; URETHRA; TRACT; INVITRO;
Keywords:
bladder; blood flow; obstruction; distension; smooth muscle; rabbit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Levin, RM Albany Coll Pharm, Div Basic & Pharmaceut Sci, 106 New Scotland Ave, Albany, NY 12208 USA Albany Coll Pharm 106 New Scotland Ave Albany NY USA 12208 8 USA
Citazione:
J. Lieb et al., "The effect of urine volume and nitric oxide on basal bladder blood flow: Response to catheterization and drainage", NEUROUROL U, 20(1), 2001, pp. 115-124

Abstract

Preliminary studies demonstrated that catheterization and drainage of the urinary bladder resulted in a significant increase in blood flow to the bladder. The objectives of this study were to determine 1) the relationship between urine volume and basal blood flow to the bladder smooth muscle and mucosa, 2) the effect of acute catheterization and drainage on bladder mucosal and smooth muscle blood now, and 3) whether nitric oxide was involved in regulation of basal blood now or the increase in blood flow observed after catheterization and bladder drainage. Twenty-four rabbits were separated into two groups: group 1 (14 rabbits) and group 2 (10 rabbits) treated with L-NAME (NOS inhibitor) 30 minutes before blood now measurement. Blood flow was measured in all animals using a fluorescent microsphere technique beforeand immediately after catheterization and drainage of the bladder. The results demonstrated that 1) blood flow to the muscle and mucosa were independent of urine volume at the time of catheterization and drainage; 2) catheterization and drainage significantly increased blood now to both the bladdersmooth muscle and bladder mucosa, but not to the kidney; 3) L-NAME significantly reduced basal blood now to the kidney, but not to the bladder smoothmuscle or mucosa: and 4) L-NAME completely prevented the catheterization- and drainage-induced increases in blood flow to the bladder body mucosa andmuscle. This study demonstrates that basal blood flow to the bladder smooth muscle and mucose during filling is independent of NO control: although bladder blood flow may be increased significantly by NO synthesis and release during bladder emptying, and thus may be an important regulator of blood flow during and immediately Following micturition. Neurourol. Urodynam. 20:115-124, 2001. (C) Wiley-Liss, Inc.

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Documento generato il 03/04/20 alle ore 02:40:50