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Titolo:
Role of dopamine D1 and D2 receptors in the micturition reflex in conscious rats
Autore:
Seki, S; Igawa, Y; Kaidoh, K; Ishizuka, O; Nishizawa, O; Andersson, KE;
Indirizzi:
Shinshu Univ, Sch Med, Dept Urol, Matsumoto, Nagano 3908621, Japan ShinshuUniv Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Univ Lund Hosp, Dept Clin Pharmacol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Clin Pharmacol, S-22185 Lund, Sweden
Titolo Testata:
NEUROUROLOGY AND URODYNAMICS
fascicolo: 1, volume: 20, anno: 2001,
pagine: 105 - 113
SICI:
0733-2467(2001)20:1<105:RODDAD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DETRUSOR HYPERREFLEXIA; PARKINSONS-DISEASE; BLADDER;
Keywords:
cystometry; detrusor hyperreflexia; bladder function; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Igawa, Y Shinshu Univ, Sch Med, Dept Urol, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3908621 21, Japan
Citazione:
S. Seki et al., "Role of dopamine D1 and D2 receptors in the micturition reflex in conscious rats", NEUROUROL U, 20(1), 2001, pp. 105-113

Abstract

To clarify the role of dopamine D1 and D2 receptors in the volume-induced micturition reflex, conscious, female rats were investigated cystometrically before and after intravenous administration of SKF 38393 (a selective D1 receptor agonist), SCH 23390 (a selective D1 receptor antagonist), quinpirole (a selective D2 receptor agonist), and remoxipride (a selective D2 receptor antagonist). The effect of quinpirole was also investigated in the presence of remoxipride. Intravenous administration of SKF 38393 (0.01-3.0 mg/kg) did not affect any cystometric parameters investigated. On the other hand, SCH 23390 (0.1-1.0 mg/kg i.v.) reduced bladder capacity and micturition volumes and increased the micturition pressure in a dose-dependent manner. Quinpirole (0.01-0.1 mg/kg) given intravenously, dose-dependently decreasedbladder capacity and micturition volumes. Pre-treatment with remoxipride (1.0 mg/kg i.v.) significantly attenuated the effect of quinpirole (0.1 mg/kg i.v..). Remoxipride (0.1-1.0 mg i.v.) itself did not cause any significant changes in the cystometric parameters. These results suggest that in conscious rats, DI receptors tonically inhibit the micturition reflex and that D2 receptors are involved in facilitation of the micturition reflex. It maybe speculated that detrusor hyperreflexia associated with Parkinson's disease results fi om activation failure of D1 receptors and that administration of D2 receptor agonists might worsen the condition. Neurourol. Urodynam. 20:105-113. 2001. (C) 2001 Wiley-Liss. Inc

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:34:18