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Titolo:
Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues
Autore:
Hino, H; Akiyama, H; Iseki, E; Kato, M; Kondo, H; Ikeda, K; Kosaka, K;
Indirizzi:
Tokyo Inst Psychiat, Setagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 etagaya Ku, Tokyo 1568585, Japan Yokohama City Univ, Sch Med, Dept Psychiat, Yokohama, Kanagawa 232, Japan Yokohama City Univ Yokohama Kanagawa Japan 232 ohama, Kanagawa 232, Japan Yokohama Maioka Hosp, Yokohama, Kanagawa, Japan Yokohama Maioka Hosp Yokohama Kanagawa Japan , Yokohama, Kanagawa, Japan Soga Hosp, Odawara, Kanagawa, Japan Soga Hosp Odawara Kanagawa JapanSoga Hosp, Odawara, Kanagawa, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 297, anno: 2001,
pagine: 105 - 108
SICI:
0304-3940(20010112)297:2<105:ILOPAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; SYSTEM; VITRONECTIN; STIMULATION; ALZHEIMER; MIGRATION; RECEPTOR; PROTEIN; GROWTH;
Keywords:
neuron; astrocyte; Alzheimer's disease; fibrinolysis; serpin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Akiyama, H Tokyo Inst Psychiat, Setagaya Ku, 2-1-8 Kamikitazawa, Tokyo 1568585, Japan Tokyo Inst Psychiat 2-1-8 Kamikitazawa Tokyo Japan 1568585 pan
Citazione:
H. Hino et al., "Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues", NEUROSCI L, 297(2), 2001, pp. 105-108

Abstract

We investigated immunohistochemically the localization of type 1 plasminogen activator inhibitor (PAI-1) in rat and human brain tissues. In rat, neurons and astrocytes were stained positively for PAI-1 after colchicine treatment. In postmortem human brain, neurons were stained for PAI-1 but the number of positive neurons varied greatly from case to case. PAI-1 positive astrocytes occurred in the white matter lesions of some patients. In Alzheimer's disease, weak PAI-1 labeling was seen in association with senile plaques and ghost tangles. The present results support a notion that PAI-1 and its target proteases such as plasminogen activators and thrombin are involvedin a variety of physiological and pathological processes in brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:14:35