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Titolo:
Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomographyprovocation study
Autore:
Fernandez, M; Pissiota, A; Frans, O; von Knorring, L; Fischer, H; Fredrikson, M;
Indirizzi:
Dept Psychol, SE-75142 Uppsala, Sweden Dept Psychol Uppsala Sweden SE-75142 t Psychol, SE-75142 Uppsala, Sweden Univ Uppsala Hosp, Dept Neurosci Psychiat, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden ept Neurosci Psychiat, Uppsala, Sweden Massachusetts Gen Hosp, Psychiat Neuroimaging Grp, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ging Grp, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Uppsala Univ, PET Ctr, Uppsala, Sweden Uppsala Univ Uppsala SwedenUppsala Univ, PET Ctr, Uppsala, Sweden
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 297, anno: 2001,
pagine: 101 - 104
SICI:
0304-3940(20010112)297:2<101:BFIAPW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CHILDHOOD SEXUAL ABUSE; SCRIPT-DRIVEN IMAGERY; PET; NEUROANATOMY; MEMORIES; PTSD; FEAR;
Keywords:
torture; anxiety; fear; positron emission tomography; neuroimaging; regional cerebral blood-flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Fredrikson, M Dept Psychol, Box 1225, SE-75142 Uppsala, Sweden Dept Psychol Box 1225 Uppsala Sweden SE-75142 psala, Sweden
Citazione:
M. Fernandez et al., "Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomographyprovocation study", NEUROSCI L, 297(2), 2001, pp. 101-104

Abstract

We report positron emission tomographic measurements of regional cerebral blood flow (rCBF) in a male patient with war and torture related post-traumatic stress disorder (PTSD) du ring symptom provocation. The subject was exposed to war related sounds before and after treatment with a selective serotonin reuptake inhibitor (SSRI; Fluoxetine; Fontex(R)). Therapy reduced PTSD symptoms, provoked anxiety and heart rate. Before treatment trauma reminders resulted in decreased rCBF in the insula, prefrontal, and inferior frontal cortices. Increased activity was evident in the cerebellum, precuneus and supplementary motor cortex. This was normalized after SSRI administration. Prefrontal and cingulate rCBF correlated with heart rate. Hence, the anxiolytic effect of SSRI for PTSD could be mediated by prefrontal and paralimbic cortices. Data suggest that SSRI treatment normalize provocation induced rCBF alterations in areas involved in memory, emotion, attention and motor-control. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:37:11