Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus
Autore:
Shahlaie, K; Kargozaran, H; Horowitz, JM;
Indirizzi:
Univ Calif Davis, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA UnivCalif Davis Davis CA USA 95616 Physiol & Behav, Davis, CA 95616 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 297, anno: 2001,
pagine: 85 - 88
SICI:
0304-3940(20010112)297:2<85:ACIPOE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ARACHIDONIC-ACID CONCENTRATION; SYNAPTIC PLASTICITY; F344 RATS; MECHANISMS; INDUCTION; DECREASE; MEMORY; NEUROSCIENCE; IMPAIRMENT;
Keywords:
neural plasticity; long-term potentiation; aging; CA1 pyramidal cells; hippocampus; Mesocricetus auratus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Horowitz, JM Univ Calif Davis, Sect Neurobiol Physiol & Behav, 1 Shields Ave, Davis, CA95616 USA Univ Calif Davis 1 Shields Ave Davis CA USA 95616 CA95616 USA
Citazione:
K. Shahlaie et al., "Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus", NEUROSCI L, 297(2), 2001, pp. 85-88

Abstract

Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 +/- 20.0% in slices from young animals and by 51.1 +/- 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 +/- 68.4% in slices from young animals and by 13.7 +/- 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:17:28