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Titolo:
Choroid plexus epithelial cells in adult rats show structural alteration but not apoptosis following an exposure to hypobaric hypoxia
Autore:
Wang, D; Kaur, C;
Indirizzi:
Natl Univ Singapore, Fac Med, Dept Anat, Singapore 117597, Singapore Natl Univ Singapore Singapore Singapore 117597 ngapore 117597, Singapore
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 297, anno: 2001,
pagine: 77 - 80
SICI:
0304-3940(20010112)297:2<77:CPECIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; CEREBRAL-ISCHEMIA; EPIPLEXUS CELLS; BRAIN; ADAPTATION; RESPONSES; INDUCTION; INJURY; DEATH; BCL-2;
Keywords:
altitude; choroid plexus epithelial cells; caspase-3; Bcl-2; Bax;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kaur, C Natl Univ Singapore, Fac Med, Dept Anat, MD 10,4 Med Dr, Singapore117597,Singapore Natl Univ Singapore MD 10,4 Med Dr Singapore Singapore 117597 ore
Citazione:
D. Wang e C. Kaur, "Choroid plexus epithelial cells in adult rats show structural alteration but not apoptosis following an exposure to hypobaric hypoxia", NEUROSCI L, 297(2), 2001, pp. 77-80

Abstract

The choroid plexus in adult rats was examined for any structural alteration or apoptotic cell death following a high altitude exposure which leads tothe development of hypobaric hypoxia due to reduced oxygen tension in the atmospheric air. Caspase-3 (a protease which mediates apoptosis) immunoreactivity was absent in the choroid plexus epithelial cells in the control rats and following altitude exposure; Bcl-2 (anti-apoptotic protein) and Bax (pro-apoptotic protein) immunoreactivity were upregulated at 3 h-2 days following the altitude exposure when compared to the controls but not in longersurviving rats. At the ultrastructural level, glycogen particles and vacuoles were observed in some epithelial cells at 7 days following the altitudeexposure. It is suggested that transient exposure to high altitude may notcause much damage to the choroid plexus epithelial cells except for some structural alteration which may be due to altered metabolism of the cells inresponse to hypobaric hypoxia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:21:46