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Titolo:
SADS: A new component of Fas-DISC is the accelerator for cell death signaling and is downregulated in patients with colon carcinoma
Autore:
Suzuki, A; Obata, S; Hayashida, M; Kawano, H; Nakano, T; Shiraki, K;
Indirizzi:
Daiichi Pharmaceut Co Ltd, Basic Technol Res Lab, Project Cell Death Res, Tokyo R&D Ctr,Edogawa Ku, Tokyo 1348630, Japan Daiichi Pharmaceut Co Ltd Tokyo Japan 1348630 a Ku, Tokyo 1348630, Japan Kishida Chem Co Ltd, Sanda Factory, Res & Dev Grp, Biochem Lab, Sanda, Hyogo 6691339, Japan Kishida Chem Co Ltd Sanda Hyogo Japan 6691339 Sanda, Hyogo 6691339, Japan Mie Univ, Sch Med, Dept Internal Med 1, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 pt Internal Med 1, Tsu, Mie 5148507, Japan
Titolo Testata:
NATURE MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 88 - 93
SICI:
1078-8956(200101)7:1<88:SANCOF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED APOPTOSIS; PROTEASE; INVOLVEMENT; RECEPTOR; ANTIGEN; ACTIVATION; PATHWAYS; COMPLEX; FADD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, A Daiichi Pharmaceut Co Ltd, Basic Technol Res Lab, Project Cell Death Res, Tokyo R&D Ctr,Edogawa Ku, Kitakasai 1-16-13, Tokyo 1348630, JapanDaiichi Pharmaceut Co Ltd Kitakasai 1-16-13 Tokyo Japan 1348630
Citazione:
A. Suzuki et al., "SADS: A new component of Fas-DISC is the accelerator for cell death signaling and is downregulated in patients with colon carcinoma", NAT MED, 7(1), 2001, pp. 88-93

Abstract

Fas is the death receptor, transducing cell death signaling upon stimulation by Fas ligand. During Fas-initiated cell death signaling, the formation of Fas-death inducing signaling complex (Fas-DISC) is the first step. Here we have identified a new component of Fas-DISC which we call 'small-accelerator for death signaling' (SADS). SADS cDNA encodes a 150 amino acid polypeptide (Mr = 16,700). During Fas-mediated cell death, SADS enhances the interaction of Fas-death domain-interactive factors (FADD) and procaspase-8, and deletion mutant analysis has identified FADD- and caspase-8-interactive domains in SADS. Inhibition or removal of SADS delays Fas-mediated cell death. In addition, we demonstrate the deletion or mutation of SADS in patientswith colon carcinoma and that exogenous SADS expression in human colon carcinoma SW480 cells that lack SADS leads to re-acquisition of Fas-mediated cell death. Here, we propose that SADS is one of the cell death-associated factors and enhances Fas-DISC formation, especially FADD and procaspase-8 recruitment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:24:43