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Titolo:
Increased production of IL-7 accompanies HIV-l-mediated T-cell depletion: implications for T-cell homeostasis
Autore:
Napolitano, LA; Grant, RM; Deeks, SG; Schmidt, D; De Rosa, SC; Herzenberg, LA; Herndier, BG; Andersson, J; McCune, JM;
Indirizzi:
San Francisco Gen Hosp, Gladstone Inst Virol & Immunol, San Francisco, CA 94110 USA San Francisco Gen Hosp San Francisco CA USA 94110 Francisco, CA 94110 USA Univ Calif San Francisco, Dept Med, San Francisco, CA 94110 USA Univ CalifSan Francisco San Francisco CA USA 94110 ancisco, CA 94110 USA Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94110 USA Univ Calif San Francisco San Francisco CA USA 94110 ancisco, CA 94110 USA Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94110 USA Univ Calif San Francisco San Francisco CA USA 94110 ancisco, CA 94110 USA Stanford Univ, Dept Genet, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 v, Dept Genet, Stanford, CA 94305 USA Huddinge Univ Hosp, Karolinska Inst, Dept Infect Dis, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden Dept Infect Dis, Stockholm, Sweden
Titolo Testata:
NATURE MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 73 - 79
SICI:
1078-8956(200101)7:1<73:IPOIAH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-DEFICIENT MICE; BONE-MARROW TRANSPLANT; THYMIC FUNCTION; GROWTH-HORMONE; INTERLEUKIN-7; INFECTION; LYMPHOCYTES; IMMUNODEFICIENCY; PROLIFERATION; LYMPHOPOIESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: McCune, JM San Francisco Gen Hosp, Gladstone Inst Virol & Immunol, San Francisco, CA 94110 USA San Francisco Gen Hosp San Francisco CA USA 94110 CA 94110 USA
Citazione:
L.A. Napolitano et al., "Increased production of IL-7 accompanies HIV-l-mediated T-cell depletion: implications for T-cell homeostasis", NAT MED, 7(1), 2001, pp. 73-79

Abstract

We hypothesized that HIV-1-mediated T-cell loss might induce the production of factors that are capable of stimulating lymphocyte development and expansion. Here we perform cross-sectional (n = 168) and longitudinal (n = 11)analyses showing that increased circulating levels of interleukin (IL)-7 are strongly associated with CD4+ T lymphopenia in HIV-1 disease. Using immunohistochemistry with quantitative image analysis, we demonstrate that IL-7is produced by dendritic-like cells within peripheral lymphoid tissues andthat IL-7 production by these cells is greatly increased in lymphocyte-depleted tissues. We propose that IL-7 production increases as part of a homeostatic response to T-cell depletion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:38:50