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Titolo:
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake
Autore:
Moore, KJ; Rosen, ED; Fitzgerald, ML; Randow, F; Andersson, LP; Altshuler, D; Milstone, DS; Mortensen, RM; Spiegelman, BM; Freeman, MW;
Indirizzi:
Massachusetts Gen Hosp, Dept Med, Lipid Metab Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 tab Unit, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Dana Farber Canc Inst, Dept Cell Biol, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115 Cell Biol, Boston, MA 02115 USA Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Mol Biol, Boston, MA 02114 USA MIT, Whitehead Inst Biomed Res, Ctr Genome Res, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 d Res, Ctr Genome Res, Cambridge, MA 02139 USA Brigham & Womens Hosp, Dept Pathol, Div Vasc Res, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Vasc Res, Boston, MA 02115 USA Univ Michigan, Dept Physiol, Div Endocrine, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 v Endocrine, Ann Arbor, MI 48109 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 41 - 47
SICI:
1078-8956(200101)7:1<41:TROPIM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED RECEPTOR-GAMMA; LOW-DENSITY-LIPOPROTEIN; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); SCAVENGER RECEPTORS; AFFINITY LIGAND; GENE-EXPRESSION; RETINOIC ACID; OXIDIZED LDL; HUMAN CD36; IN-VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Freeman, MW Massachusetts Gen Hosp, Dept Med, Lipid Metab Unit, Boston, MA02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ston, MA 02114 USA
Citazione:
K.J. Moore et al., "The role of PPAR-gamma in macrophage differentiation and cholesterol uptake", NAT MED, 7(1), 2001, pp. 41-47

Abstract

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), the transcription factor target of the anti-diabetic thiazolidinedione (TZD) drugs, isreported to mediate macrophage differentiation and inflammatory responses. Using PPAR-gamma -deficient stem cells, we demonstrate that PPAR-gamma is neither essential for myeloid development, nor for such mature macrophage functions as phagocytosis and inflammatory cytokine production. PPAR-gamma is required for basal expression of CD36, but not for expression of the other major scavenger receptor responsible for uptake of modified lipoproteins,SR-A. In wild-type macrophages, TZD treatment divergently regulated CD36 and class A macrophage-scavenger receptor expression and failed to induce significant cellular cholesterol accumulation, indicating that TZDs may not exacerbate macrophage foam-cell formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 01:38:24