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Titolo:
ROLE OF CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT (CINC) IN OZONE-INDUCED AIRWAY INFLAMMATION AND HYPERRESPONSIVENESS
Autore:
KOTO H; SALMON M; HADDAD EB; HUANG TJ; ZAGORSKI J; CHUNG KF;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,NATL HEART & LUNG INST,DEPT THORAC MED,DOVEHOUSE ST LONDON SW3 6LY ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,NATL HEART & LUNG INST,DEPT THORAC MED LONDON SW3 6LY ENGLAND NIH BETHESDA MD 20892
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 156, anno: 1997,
pagine: 234 - 239
SICI:
1073-449X(1997)156:1<234:ROCNC(>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR KAPPA-B; NECROSIS-FACTOR-ALPHA; FUNCTIONAL-CHARACTERIZATION; BRONCHIAL HYPERREACTIVITY; INTERLEUKIN-8 FAMILY; TRANSCRIPTION FACTOR; CHEMOTACTIC FACTOR; GUINEA-PIGS; CELL-LINE; RAT CINC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Koto et al., "ROLE OF CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT (CINC) IN OZONE-INDUCED AIRWAY INFLAMMATION AND HYPERRESPONSIVENESS", American journal of respiratory and critical care medicine, 156(1), 1997, pp. 234-239

Abstract

Cytokine-induced neutrophil chemoattractant (CINC) is a rat chemokinewith potent chemoattractant effects on neutrophils, We determined theinvolvement of CINC in ozone-induced airway neutrophilia and bronchial hyperresponsiveness (BHR) in the rat. We found a marked increase in lung CINC messenger RNA (mRNA) within 2 h after cessation of ozone exposure (1 ppm for 3 h), as measured by Northern blot analysis, whereas rats exposed to room air had no detectable CINC mRNA. Ozone exposure induced a significant neutrophilia in bronchoalveolar lavage fluid (BALF) at 24 h after exposure (air-exposed rats: 4.2 +/- 2.0 x 10(4) versus ozone-exposed rats: 16.1 +/- 3.7 x 10(4)); prior treatment with a goat anti-CINC antibody (1 mg, intravenously) suppressed the neutrophilia (3.1 +/- 0.9 x 10(4)). When administered intratracheally, the antibody (230 mu g) partially inhibited the influx of neutrophils. The increase in bronchial responsiveness to acetylcholine observed after ozone exposure was not inhibited by the anti-CINC antibody. The anti-CINC antibody (1 mg, intravenousIy) also inhibited BALF neutrophilia induced by exposure to a higher concentration of ozone (3 ppm, 3 h), without an effect on BHR. CINC is an important chemokine causing ozone-induced neutrophil chemoattraction, but is not involved in the induction of ozone-induced BHR. The neutrophil is unlikely to contribute to BHR in this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:45:38