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Titolo:
On guard - activating NK cell receptors
Autore:
Lanier, LL;
Indirizzi:
Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 1, volume: 2, anno: 2001,
pagine: 23 - 27
SICI:
1529-2908(200101)2:1<23:OG-ANC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; PROTEIN-TYROSINE KINASE; DELTA T-CELLS; FC-GAMMA-RIII; PHOSPHATIDYLINOSITOL 3-KINASE; CUTTING EDGE; SIGNAL-TRANSDUCTION; MOLECULAR CHARACTERIZATION; COSTIMULATORY SIGNALS; INHIBITORY RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Lanier, LL Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
L.L. Lanier, "On guard - activating NK cell receptors", NAT IMMUNOL, 2(1), 2001, pp. 23-27

Abstract

Although natural killer (NK) cells are known to preferentially kill cells that tack major histocompatibility complex class I antigens, we do not knowwhat signals the attack of these targets. Several membrane receptors have recently been implicated in this process and include molecules with immunoreceptor tyrosine-based activation motifs (ITAM) and motifs that bind phosphoinositide-3 kinase (P13K). Evidence is emerging that NK cells may use a combination of several receptors and signaling pathways to protect the host against infection and possibly against malignancies.

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Documento generato il 04/04/20 alle ore 01:32:09