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Titolo:
Transcriptional regulation and function during the human cell cycle
Autore:
Cho, RJ; Huang, MX; Campbell, MJ; Dong, HL; Steinmetz, L; Sapinoso, L; Hampton, G; Elledge, SJ; Davis, RW; Lockhart, DJ;
Indirizzi:
Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 d, Dept Genet, Stanford, CA 94305 USA Baylor Coll Med, Howard Hughes Med Inst, Dept Biochem & Mol Biol, Dept Mol& Human Genet, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA Affymetrix Inc, Santa Clara, CA USA Affymetrix Inc Santa Clara CA USAAffymetrix Inc, Santa Clara, CA USA Stanford Univ, Sch Med, Dept Biochem, Stanford, CA USA Stanford Univ Stanford CA USA v, Sch Med, Dept Biochem, Stanford, CA USA Mol Applicat Grp, Palo Alto, CA USA Mol Applicat Grp Palo Alto CA USAMol Applicat Grp, Palo Alto, CA USA Novartis Res Fdn, Genomics Inst, San Diego, CA USA Novartis Res Fdn San Diego CA USA Fdn, Genomics Inst, San Diego, CA USA Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
NATURE GENETICS
fascicolo: 1, volume: 27, anno: 2001,
pagine: 48 - 54
SICI:
1061-4036(200101)27:1<48:TRAFDT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASODILATOR-STIMULATED PHOSPHOPROTEIN; THYMOCYTE APOPTOSIS; BINDING; EXPRESSION; PROTEIN; GENE; FAMILY; KINASE; DEATH; RHO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Campbell, MJ Celera Genomics, Foster City, CA USA Celera Genomics Foster City CA USA ics, Foster City, CA USA
Citazione:
R.J. Cho et al., "Transcriptional regulation and function during the human cell cycle", NAT GENET, 27(1), 2001, pp. 48-54

Abstract

We report here the transcriptional profiling of the cell cycle on a genome-wide scale in human fibroblasts. We identified approximately 700 genes that display transcriptional fluctuation with a periodicity consistent with that of the cell cycle. Systematic analysis of these genes revealed functional organization within groups of coregulated transcripts. A diverse set of cytoskeletal reorganization genes exhibit cell-cycle-dependent regulation, indicating that biological pathways are redirected for the execution of celldivision. Many genes involved in cell motility and remodeling of the extracellular matrix are expressed predominantly in M phase, indicating a mechanism for balancing proliferative and invasive cellular behavior. Transcriptsupregulated during S phase displayed extensive overlap with genes induced by DNA damage; cell-cycle-regulated transcripts may therefore constitute coherent programs used in response to external stimuli. Our data also provideclues to biological function for hundreds of previously uncharacterized human genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:36:10