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Titolo:
A biochemical function for attractin in agouti-induced pigmentation and obesity
Autore:
He, L; Gunn, TM; Bouley, DM; Lu, XY; Watson, SJ; Schlossman, SF; Duke-Cohan, JS; Barsh, GS;
Indirizzi:
Stanford Univ, Sch Med, Dept Pediat & Genet, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ediat & Genet, Stanford, CA 94305 USA Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ghes Med Inst, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Comparat Med, Stanford, CA 94305 USA StanfordUniv Stanford CA USA 94305 Comparat Med, Stanford, CA 94305 USA Univ Michigan, Sch Med, Mental Hlth Res Inst, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA , Mental Hlth Res Inst, Ann Arbor, MI USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA USA Harvard Univ Boston MA USA nst, Dept Canc Immunol & AIDS, Boston, MA USA
Titolo Testata:
NATURE GENETICS
fascicolo: 1, volume: 27, anno: 2001,
pagine: 40 - 47
SICI:
1061-4036(200101)27:1<40:ABFFAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATING-HORMONE-RECEPTOR; YELLOW A(Y) MUTATION; MELANOCORTIN RECEPTORS; TRANSGENIC MICE; COAT COLOR; NERVOUS-SYSTEM; IN-VITRO; PROTEIN; MOUSE; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Barsh, GS Stanford Univ, Sch Med, Dept Pediat & Genet, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 net, Stanford, CA 94305 USA
Citazione:
L. He et al., "A biochemical function for attractin in agouti-induced pigmentation and obesity", NAT GENET, 27(1), 2001, pp. 40-47

Abstract

Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (A(y)) mice, and causes obesity bymimicking agouti-related protein (Agrp), found primarily in the hypothalamus. Mouse attractin (Atrn) is a widely expressed transmembrane protein whose loss of function in mahogany (Atrn(mg-3J)/Atrn(mg-3J)) mutant mice blocksthe pleiotropic effects of A(y). Here we demonstrate in transgenic, biochemical and genetic-interaction experiments that attractin is a low-affinity receptor for agouti protein, but not Agrp, in vitro and in vivo. Additionalhistopathologic abnormalities in Atrn(mg-3J)/Atrn(mg-3J) mice and cross-species genomic comparisons indicate that Atrn has multiple functions distinct from both a physiologic and an evolutionary perspective.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 22:04:28