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Titolo:
Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization
Autore:
Stevenson, VA; Kramer, J; Kuhn, J; Theurkauf, WE;
Indirizzi:
Univ Massachusetts, Med Ctr, Program Mol Med, Worcester, MA 01605 USA UnivMassachusetts Worcester MA USA 01605 ol Med, Worcester, MA 01605 USA Univ Massachusetts, Med Ctr, Dept Mol Genet & Microbiol, Worcester, MA 01605 USA Univ Massachusetts Worcester MA USA 01605 robiol, Worcester, MA 01605 USA SUNY Stony Brook, Dept Cell Biol & Biochem, Stony Brook, NY 11794 USA SUNYStony Brook Stony Brook NY USA 11794 chem, Stony Brook, NY 11794 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 1, volume: 3, anno: 2001,
pagine: 68 - 75
SICI:
1465-7392(200101)3:1<68:CATSPC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA EMBRYOS; SYNCYTIAL BLASTODERM; INSERTIONAL MUTAGENESIS; EARLY EMBRYOGENESIS; F-ACTIN; CYTOSKELETON; MIGRATION; CLEAVAGE; NUCLEAR; ORGANIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Theurkauf, WE Univ Massachusetts, Med Ctr, Program Mol Med, 373 Plantat St, Worcester, MA 01605 USA Univ Massachusetts 373 Plantat St Worcester MA USA 01605 USA
Citazione:
V.A. Stevenson et al., "Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization", NAT CELL BI, 3(1), 2001, pp. 68-75

Abstract

In Drosophila syncytial blastoderm embryos, centrosomes specify the position of actin-based interphase caps and mitotic furrows. Mutations in the scrambled locus prevent assembly of mitotic furrows, but do not block actin cap formation. The scrambled gene encodes a protein that localizes to the mitotic furrows and centrosomes, Seed localization, actin reorganization from caps into mitotic furrows, and centrosome-coordinated assembly of actin caps are not blocked by microtubule disruption. Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:49:32