Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor
Autore:
Mazumdar, A; Wang, RA; Mishra, SK; Adam, L; Bagheri-Yarmand, R; Mandal, M; Vadlamudi, RK; Kumar, R;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 l & Cellular Oncol, Houston, TX 77030 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 1, volume: 3, anno: 2001,
pagine: 30 - 37
SICI:
1465-7392(200101)3:1<30:TROORB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER CELLS; HISTONE DEACETYLASE; ESTROGEN-RECEPTOR; PROMYELOCYTIC LEUKEMIA; GENE; EXPRESSION; COMPLEX; YEAST; OVEREXPRESSION; ACETYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, R Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515HolcombeBlvd, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd Houston TX USA 77030 , TX 77030 USA
Citazione:
A. Mazumdar et al., "Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor", NAT CELL BI, 3(1), 2001, pp. 30-37

Abstract

Activation of the heregulin/HER2 pathway in oestrogen receptor (ER)-positive breast-cancer cells leads to suppression of oestrogen-receptor element (ERE)-driven transcription and disruption of oestradiol responsiveness, and thus contributes to progression of tumours to more invasive phenotypes. Here we report the identification of metastatic-associated protein 1 (MTA1), acomponent of histone deacetylase (HDAC) and nucleosome-remodelling complexes, as a gene product induced by heregulin-beta1 (HRG). Stimulation of cells with HRG is accompanied by suppression of histone acetylation and enhancement of deacetylase activity. MTA1 is also a potent corepressor of ERE transcription, as it blocks the ability of oestradiol to stimulate ER-mediated transcription. The histone-deacetylase inhibitor trichostatin A blocks MTA1-mediated repression of ERE transcription, Furthermore, MTA1 directly interacts with histone deacetylase-l and -2 and with the activation domain of ER-alpha. Overexpression of MTA1 in breast-cancer cells is accompanied by enhancement of the ability of cells to invade and to grow in an anchorage-independent manner. HRG also promotes interaction of MTA1 with endogenous ER and association of MTA1 or HDAC with ERE-responsive target-gene promoters in vivo. These results identify ER-mediated transcription as a nuclear target of MTA1 and indicate that HDAC complexes associated with the MTA1 corepressor may mediate ER transcriptional repression by HRG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:36:27