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Titolo:
The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues
Autore:
Lindsten, T; Ross, AJ; King, A; Zong, WX; Rathmell, JC; Shiels, HA; Ulrich, E; Waymire, KG; Mahar, P; Frauwirth, K; Chen, YF; Wei, M; Eng, VM; Adelman, DM; Simon, MC; Ma, A; Golden, JA; Evan, G; Korsmeyer, SJ; MacGregor, GR; Thompson, CB;
Indirizzi:
Univ Penn, Abramson Family Canc Res Inst, Dept Med, Philadelphia, PA 19104USA Univ Penn Philadelphia PA USA 19104 , Dept Med, Philadelphia, PA 19104USA Univ Penn, Abramson Family Canc Res Inst, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA Emory Univ, Sch Med, Grad Program Biochem Cell & Dev Biol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 em Cell & Dev Biol, Atlanta, GA 30322 USA Univ Chicago, Dept Med, Chicago, IL 60637 USA Univ Chicago Chicago IL USA60637 hicago, Dept Med, Chicago, IL 60637 USA Univ Calif San Francisco, Ctr Canc, Inst Canc Res, San Francisco, CA 94143USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA 94143USA Emory Univ, Sch Med, Ctr Mol Med, Atlanta, GA USA Emory Univ Atlanta GA USA ry Univ, Sch Med, Ctr Mol Med, Atlanta, GA USA Univ Penn, Univ Lab Anim Resources, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Resources, Philadelphia, PA 19104 USA Univ Penn, Abramson Family Canc Res Inst, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dev Biol, Philadelphia, PA 19104 USA Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Med Inst, Philadelphia, PA 19104 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 d Inst,Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med Inst,Dept Med, Boston, MA 02115 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 6, volume: 6, anno: 2000,
pagine: 1389 - 1399
SICI:
1097-2765(200012)6:6<1389:TCFOPB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; CYTOCHROME-C; DEFICIENT MICE; THYMOCYTE APOPTOSIS; BRAIN-DEVELOPMENT; PROTEIN FAMILY; HOMOLOG BAK; IN-VIVO; MITOCHONDRIA; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, CB Univ Penn, Abramson Family Canc Res Inst, Dept Med, Philadelphia, PA 19104USA Univ Penn Philadelphia PA USA 19104 hiladelphia, PA 19104USA
Citazione:
T. Lindsten et al., "The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues", MOL CELL, 6(6), 2000, pp. 1389-1399

Abstract

Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficientmice to create mice lacking both genes, the majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:54:38