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Titolo:
Benzafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue
Autore:
Vasquez, M; Roglans, N; Cabrero, A; Rodriguez, C; Adzet, T; Alegret, M; Sanchez, RM; Laguna, JC;
Indirizzi:
Univ Barcelona, Fac Farm, Unidad Farmacol & Farmacognosia, Dept Farmacol &Quim Terapeut, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 erapeut, E-08028 Barcelona, Spain
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 216, anno: 2001,
pagine: 71 - 78
SICI:
0300-8177(200101)216:1-2<71:BIAOML>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED RECEPTOR-ALPHA; PPAR-ALPHA; LIPID-METABOLISM; GENE-EXPRESSION; DEFICIENT MICE; OBESE GENE; PROLIFERATION; TRANSCRIPTION; LIPOPROTEINS; ADIPOGENESIS;
Keywords:
PPAR; bezafibrate; leptin; acyl-CoA oxidase; white adipose tissue; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Laguna, JC Univ Barcelona, Fac Farm, Unidad Farmacol & Farmacognosia, DeptFarmacol &Quim Terapeut, Nucl Univ Pedralbes, E-08028 Barcelona, Spain Univ Barcelona Nucl Univ Pedralbes Barcelona Spain E-08028 ain
Citazione:
M. Vasquez et al., "Benzafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue", MOL C BIOCH, 216(1-2), 2001, pp. 71-78

Abstract

Rats treated with bezafibrate, a PPAR activator, gain less body weight andincrease daily food intake. Previously, we have related these changes to ashift of thermogenesis from brown adipose tissue to white adipose tissue attributable to bezafibrate, which induces uncoupling proteins (UCP), UCP-1 and UCP-3, in rat white adipocytes. Nevertheless, UCP induction was weak, implying additional mechanisms in the change of energy homeostasis produced by bezafibrate. Here we show that bezafibrate, in addition to inducing UCPs, modifies energy homeostasis by directly inducing aco gene expression and peroxisomal fatty acid beta -oxidation in white adipose tissue. Further, bezafibrate significantly reduced plasma triglyceride and leptin concentrations, without modifying the levels of PPAR gamma or ob gene in white adipose tissue. These results indicate that bezafibrate reduces the amount of fattyacids available for triglyceride synthesis in white adipose tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:49:32