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Titolo:
Short-term gemfibrozil treatment reverses lipid profile and peroxidation but does not alter blood glucose and tissue antioxidant enzymes in chronically diabetic rats
Autore:
Ozansoy, G; Akin, B; Aktan, F; Karasu, C;
Indirizzi:
Ankara Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 pt Pharmacol, TR-06100 Ankara, Turkey Ankara Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey Ankara UnivAnkara Turkey TR-06100 Dept Biochem, TR-06100 Ankara, Turkey
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 216, anno: 2001,
pagine: 59 - 63
SICI:
0300-8177(200101)216:1-2<59:SGTRLP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; COMBINED HYPERLIPIDEMIA; VITAMIN-E; AORTA; OXIDATION; METABOLITES; STRESS; HEART;
Keywords:
gemfibrozil; streptozotocin-diabetes; aorta; superoxide dismutase; catalase; glutathione peroxidase; lipid peroxidation; hyperlipidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Karasu, C Ankara Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 ol, TR-06100 Ankara, Turkey
Citazione:
G. Ozansoy et al., "Short-term gemfibrozil treatment reverses lipid profile and peroxidation but does not alter blood glucose and tissue antioxidant enzymes in chronically diabetic rats", MOL C BIOCH, 216(1-2), 2001, pp. 59-63

Abstract

In this study, we investigated the efficiency of short-term treatment withgemfibrozil in the reversal of diabetes-induced changes on carbohydrate and lipid metabolism, and antioxidant status of aorta. Diabetes was induced by a single injection of streptozotocin (45 mg/kg, i.p.). After 12 weeks of induction of diabetes, the control and diabetic rats were orally gavaged daily with a dosing vehicle alone or with 100 mg/kg of gemfibrozil for 2 weeks. At 14 weeks, there was a significant increase in blood glucose, plasma cholesterol and triglyceride levels of untreated-diabetic animals. Diabetes was associated with a significant increase in thiobarbituric acid reactive substances (TBARS) in both plasma and aortic homogenates, indicating increased lipid peroxidation. Diabetes caused an increase in vascular antioxidantenzyme activity, catalase, indicating existence of excess hydrogen peroxide (H2O2). However, superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities in aortas did not significantly change in untreated-diabetic rats. In diabetic plus gemfibrozil group both plasma lipids and lipid peroxides showed a significant recovery. Gemfibrozil treatment had no effect on blood glucose, plasma insulin and vessel antioxidant enzyme activity of diabetic animals. Our findings suggest that the beneficial effect of short-term gemfibrozil treatment in reducing lipid peroxidation in diabetic animals does not depend on a change of glucose metabolism and antioxidant statusof aorta, but this may be attributed to its decreasing effect on circulating lipids. The ability of short-term gemfibrozil treatment to recovery of metabolism and peroxidation of lipids may be an effective strategy to minimize increased oxidative stress in diabetic plasma and vasculature.

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Documento generato il 03/07/20 alle ore 22:39:45