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Titolo:
Toxicology of choroid plexus: Special reference to metal-induced neurotoxicities
Autore:
Zheng, W;
Indirizzi:
Columbia Univ, Sch Publ Hlth, Div Environm Hlth Sci, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ronm Hlth Sci, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Pharmacol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ept Pharmacol, New York, NY 10032 USA
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 1, volume: 52, anno: 2001,
pagine: 89 - 103
SICI:
1059-910X(20010101)52:1<89:TOCPSR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; PROTEIN-KINASE-C; METHYLMERCURIC CHLORIDE CH3HGCL; CEREBROSPINAL-FLUID BARRIER; GLUTATHIONE-S-TRANSFERASE; RETINOID-BINDING PROTEINS; LEVEL LEAD-EXPOSURE; RAT-BRAIN; THYROXINE TRANSPORT;
Keywords:
choroid plexus; neurotoxicity; lead; manganese; mercury; cadmium; arsenic; copper; iron; silver; zinc; gold; transthyretin; thyroxine; transferrin receptor; aconitase; protein kinase C; Alzheimer's disease; Parkinsonism; glutathione; metallothionein;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
147
Recensione:
Indirizzi per estratti:
Indirizzo: Zheng, W Columbia Univ, Sch Publ Hlth, Div Environm Hlth Sci, 60 Haven Ave,B1-112, New York, NY 10032 USA Columbia Univ 60 Haven Ave,B1-112 New York NY USA 10032 10032 USA
Citazione:
W. Zheng, "Toxicology of choroid plexus: Special reference to metal-induced neurotoxicities", MICROSC RES, 52(1), 2001, pp. 89-103

Abstract

The chemical stability in the brain underlies normal human thinking, learning, and behavior. Compelling evidence demonstrates a definite capacity of the choroid plexus in sequestering toxic heavy metal and metalloid ions. Asthe integrity of blood-brain and blood-CSF barriers, both structurally andfunctionally, is essential to brain chemical stability, the role of the choroid plexus in metal-induced neurotoxicities has become an important, yet under-investigated research area in neurotoxicology. Metals acting on the choroid plexus can be categorized into three major groups. A general choroidplexus toxicant can directly damage the choroid plexus structure such as mercury and cadmium. A selective choroid plexus toxicant may impair specificplexus regulatory pathways that are critical to brain development and function, rather than induce massive pathological alteration. The typical examples in this category include lead-induced alteration in transthyretin production and secretion as well as manganese interaction with iron in the choroid plexus. Furthermore, a sequestered choroid plexus toxicant, such as iron, silver, or gold, may be sequestered by the choroid plexus as an essentialCNS defense mechanism. Our current knowledge on the toxicological aspect of choroid plexus research is still incomplete. Thus, the future research needs have been suggested to focus on the role of choroid plexus in early CNSdevelopment as affected by metal sequestration in this tissue, to explore how metal accumulation alters the capacity of the choroid plexus in regulation of certain essential elements involved in the etiology of neurodegenerative diseases, and to better understand the blood-CSF barrier as a defense mechanism in overall CNS function. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 18:23:59