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Titolo:
Choroid plexus: Target for polypeptides and site of their synthesis
Autore:
Chodobski, A; Szmydynger-Chodobska, J;
Indirizzi:
Brown Univ, Sch Med, Dept Clin Neurosci, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 lin Neurosci, Providence, RI 02903 USA
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 1, volume: 52, anno: 2001,
pagine: 65 - 82
SICI:
1059-910X(20010101)52:1<65:CPTFPA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; AMYLOID-BETA-PROTEIN; CEREBROSPINAL-FLUID FORMATION; GROWTH-FACTOR-II; ATRIAL-NATRIURETIC-PEPTIDE; CENTRAL-NERVOUS-SYSTEM; VASOACTIVE INTESTINAL POLYPEPTIDE; ONSET ALZHEIMERS-DISEASE; FACTOR TYPE-2 RECEPTOR; CENTRAL ANGIOTENSIN-II;
Keywords:
cerebrospinal fluid formation; blood flow to choroid plexus; hormonal signaling; peptide clearance; peptide biosynthesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
222
Recensione:
Indirizzi per estratti:
Indirizzo: Chodobski, A Brown Univ, Sch Med, Dept Clin Neurosci, Aldrich Bldg,Rm 403,593 Eddy St, Providence, RI 02903 USA Brown Univ Aldrich Bldg,Rm 403,593 Eddy St Providence RI USA 02903
Citazione:
A. Chodobski e J. Szmydynger-Chodobska, "Choroid plexus: Target for polypeptides and site of their synthesis", MICROSC RES, 52(1), 2001, pp. 65-82

Abstract

Choroid plexus (CP) is an important target organ for polypeptides. The fenestrated phenotype of choroidal endothelium facilitates the penetration of blood-borne polypeptides across the capillary walls. Thus, both circulatingand cerebrospinal fluid (CSF)-borne polypeptides can reach their receptorson choroidal epithelium. Several polypeptides have been demonstrated to regulate CSF formation by controlling blood flow to choroid plexus and/or theactivity of ion transport in choroidal epithelium. However, many ligand-receptor interactions occurring in the CP are not involved in the regulation of fluid secretion. Increasing evidence suggests that the choroidal epithelium plays an important role in hormonal signaling via a receptor-mediated transport into the brain (e.g., leptin) and helps to clear certain CSF-bornepolypeptides (e.g., soluble amyloid P-protein). Thus, impaired choroidal transport or insufficient clearance of polypeptides may contribute to pathogenesis of systemic or central nervous system (CNS) disorders, such as obesity or Alzheimer's disease. CP epithelium is not only a target but is also asource of neuropeptides, growth factors, and cytokines in the CNS. These polypeptides following their release into the CSF may exert distal, endocrine-like effects on target cells in the brain due to bulk flow of this fluid. Distinct temporal patterns of choroidal expression of several polypeptidesare observed during brain development and in various CNS disorders, including traumatic brain injury and ischemia. Therefore, it is proposed that theCP plays an integral role not only in normal brain functioning, but also in the recovery from the injury. This review attempts to critically analyze the available data to support the above hypothesis. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:30:11