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Titolo:
De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of Anti-HBc positivityin the donor population
Autore:
Prieto, M; Gomez, MD; Berenguer, M; Cordoba, J; Rayon, JM; Pastor, M; Garcia-Herola, A; Nicolas, D; Carrasco, D; Orbis, JF; Mir, J; Berenguer, J;
Indirizzi:
Univ Valencia, Hosp La Fe, Serv Hepatogastroenterol, Valencia 46009, SpainUniv Valencia Valencia Spain 46009 ogastroenterol, Valencia 46009, Spain Univ Valencia, Hosp La Fe, Microbiol Serv, Valencia 46009, Spain Univ Valencia Valencia Spain 46009 Microbiol Serv, Valencia 46009, Spain Univ Valencia, Hosp La Fe, Pathol Serv, Valencia 46009, Spain Univ Valencia Valencia Spain 46009 e, Pathol Serv, Valencia 46009, Spain Univ Valencia, Hosp La Fe, Liver Transplantat & Surg Unit, Valencia 46009,Spain Univ Valencia Valencia Spain 46009 tat & Surg Unit, Valencia 46009,Spain
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 1, volume: 7, anno: 2001,
pagine: 51 - 58
SICI:
1527-6465(200101)7:1<51:DNHBAL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DE-NOVO; VIRUS; INFECTION; TRANSMISSION; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Prieto, M Univ Valencia, Hosp La Fe, Serv Hepatogastroenterol, Ave Campanar 21, Valencia 46009, Spain Univ Valencia Ave Campanar 21 Valencia Spain 46009 46009, Spain
Citazione:
M. Prieto et al., "De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of Anti-HBc positivityin the donor population", LIVER TRANS, 7(1), 2001, pp. 51-58

Abstract

Transmission of hepatitis B virus (HBV) infection from donors who are negative for hepatitis B surface antigen (HBsAg-) but positive for antibody to hepatitis B core antigen (anti-HBc+) has been reported. However, previous studies were generally performed in geographic regions with a low prevalenceof anti-HBc positivity in the liver donor population. The aims of this study are (1) to assess the risk for de novo hepatitis B in recipients of livers from anti-HBc+ donors in an area of high prevalence of anti-HBc positivity in the donor population, and (2) to analyze the risk factors for acquisition of HBV infection from anti-HBc+ donors. The transplantation experienceof a single center between 1995 and 1998 was reviewed. Thirty-three of 268liver donors (12%) were HBsAg- and anti-HBc+ during the study period. The proportion of anti-HBc+ donors increased with age; it was lowest (3.6%) in donors aged 1 to 20 years and highest (27.1%) in donors aged older than 60 years. Of the 211 HBsAg- recipients with 3 months or more of HBV serological follow-up, 30 received a liver from an anti-HBc+ donor and 181 received aliver from an anti-HBc- donor. Hepatitis B developed in 15 of 30 recipients (50%) of livers from anti-HBc+ donors but in only 3 of 181 recipients (1.7%) of livers from anti-HBc- donors (P <.0001). None of the 4 recipients who were antibody to HBsAg (anti-HBs)+ at the time of transplantation developed HBV infection after receiving a liver from an anti-HBc+ donor compared with 15 of 26 recipients (58%) who were anti-HBs- (P =.10). None of the 5 anti-HBc+ recipients developed hepatitis B compared with 15 of 25 anti-HBc-recipients (60%; P = 0.04). Child-Pugh score was significantly higher in recipients of livers from anti-HBc+ donors who developed HBV infection than in those who did not (9 +/- 2 v 7 +/- 1; P =.03). In our area, testing liver donors for anti-HBc is mandatory, particularly in older donors. With such information available, anti-HBc+ donors can be safely directed to appropriaterecipients, mainly those with anti-HBs and/or anti-HBc at the time of transplantation. In the current era of donor shortage, this policy would allow adequate use of such donors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:13:59