Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evolving trends in multiple-antibiotic-resistant bacteria in liver transplant recipients: A longitudinal study of antimicrobial susceptibility patterns
Autore:
Singh, N; Gayowski, T; Rihs, JD; Wagener, MM; Marino, IR;
Indirizzi:
Vet Affairs Med Ctr, Infect Dis Sect, Pittsburgh, PA 15240 USA Vet AffairsMed Ctr Pittsburgh PA USA 15240 ect, Pittsburgh, PA 15240 USA
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 1, volume: 7, anno: 2001,
pagine: 22 - 26
SICI:
1527-6465(200101)7:1<22:ETIMBI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROCOCCUS-FAECIUM; NOSOCOMIAL INFECTIONS; RISK-FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, N Vet Affairs Med Ctr, Infect Dis Sect, Univ Dr C, Pittsburgh, PA 15240 USA Vet Affairs Med Ctr Univ Dr C Pittsburgh PA USA 15240 A 15240 USA
Citazione:
N. Singh et al., "Evolving trends in multiple-antibiotic-resistant bacteria in liver transplant recipients: A longitudinal study of antimicrobial susceptibility patterns", LIVER TRANS, 7(1), 2001, pp. 22-26

Abstract

The incidence, sources, impact on outcome, and temporal trends in multiple-antibiotic-resistant bacteria in liver transplant recipients over the lastdecade (fi om 1990 through 1999) were assessed. Of 165 consecutive patients who: underwent transplantation, 31% (51 of 165 patients) had at least I infection caused by multiple-antibiotic-resistant bacteria. Overall, 69% (66of 96 infections) of all bacterial infections were multiple-antibiotic resistant. Ninety-one percent (45 of 49 isolates) of the Staphylococcus aureusisolates, 50% (6 of 12 isolates) of the enterococci, and 54% of the gram-negative bacteria (47%; 7 of 15 Pseudomonas aeruginosa, and 60%; 12 of 20 Enterobacteriaceae) were multiple-antibiotic resistant. A significant trend toward an increase in infections caused by multiple-antibiotic-resistant bacteria (P =.003), largely caused by an increase in gram-positive infections,was documented through the decade. There was a significant increase in infections caused by methicillin-resistant S aureus (P =.0001) and vancomycin-resistant enterococci (P =.04) over time. The proportion of gram-negative isolates that were multiple-antibiotic resistant (P =.447) did not increase significantly over time. However, a strikingly high frequency of resistanceto piperacillin or ceftazidime suggests that extended-spectrum beta -lactamase production in our Enterobacteriaceae may have been more prevalent thanrealized. Mortality at 1 year was significantly greater in patients with multiple-antibiotic-resistant bacteria compared with all other patients (P =.001). These longitudinal trends have implications not only for guiding therapeutic practices, but ultimately for devising strategies to curtail multiple-antibiotic resistance in liver transplant recipients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:48:44