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Titolo:
Long-term follow-up of childhood acute lymphoblastic leukemia in Tokyo Children's Cancer Study Group 1981-1995
Autore:
Tsuchida, M; Ikuta, K; Hanada, R; Saito, T; Isoyama, K; Sugita, K; Toyoda, Y; Manabe, A; Koike, K; Kinoshita, A; Maeda, M; Ishimoto, K; Sato, T; Okimoto, Y; Kaneko, T; Kajiwara, M; Sotomatsu, M; Hayashi, Y; Yabe, H; Hosoya, R; Hoshi, Y; Ohira, M; Bessho, F; Tsunematsu, Y; Tsukimoto, I; Nakazawa, S;
Indirizzi:
Ibaraki Childrens Hosp, Dept Pediat, Mito, Ibaraki 3114145, Japan Ibaraki Childrens Hosp Mito Ibaraki Japan 3114145 Ibaraki 3114145, Japan Yokohama City Univ, Sch Med, Dept Pediat, Yokohama, Kanagawa 232, Japan Yokohama City Univ Yokohama Kanagawa Japan 232 ohama, Kanagawa 232, Japan Yokohama City Univ, Sch Med, Dept Blood Transfus, Yokohama, Kanagawa 232, Japan Yokohama City Univ Yokohama Kanagawa Japan 232 ohama, Kanagawa 232, Japan Saitama Childrens Med Ctr, Dept Hematol & Oncol, Iwatsuki, Saitama, Japan Saitama Childrens Med Ctr Iwatsuki Saitama Japan watsuki, Saitama, Japan Childrens Natl Med Ctr, Div Environm Epidemiol, Tokyo, Japan Childrens Natl Med Ctr Tokyo Japan Div Environm Epidemiol, Tokyo, Japan Showa Univ, Fujigaoka Hosp, Sch Med, Dept Pediat, Yokohama, Kanagawa 227, Japan Showa Univ Yokohama Kanagawa Japan 227 iat, Yokohama, Kanagawa 227, Japan Dokkyo Med Coll, Dept Pediat, Div Hematol, Mibu, Tochigi, Japan Dokkyo MedColl Mibu Tochigi Japan at, Div Hematol, Mibu, Tochigi, Japan Kanagawa Childrens Med Ctr, Dept Hematol, Yokohama, Kanagawa, Japan Kanagawa Childrens Med Ctr Yokohama Kanagawa Japan hama, Kanagawa, Japan Kanagawa Childrens Med Ctr, Dept Oncol, Yokohama, Kanagawa, Japan KanagawaChildrens Med Ctr Yokohama Kanagawa Japan hama, Kanagawa, Japan Univ Tokyo, Inst Med Sci, Dept Pediat Hematol Oncol, Tokyo, Japan Univ Tokyo Tokyo Japan Med Sci, Dept Pediat Hematol Oncol, Tokyo, Japan Shinshu Univ, Dept Pediat, Sch Med, Matsumoto, Nagano 390, Japan Shinshu Univ Matsumoto Nagano Japan 390 Med, Matsumoto, Nagano 390, Japan Keio Univ, Sch Med, Dept Pediat, Tokyo 108, Japan Keio Univ Tokyo Japan 108 o Univ, Sch Med, Dept Pediat, Tokyo 108, Japan Nippon Med Sch, Dept Pediat, Tokyo 113, Japan Nippon Med Sch Tokyo Japan113 on Med Sch, Dept Pediat, Tokyo 113, Japan Juntendo Univ, Sch Med, Dept Pediat, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 iv, Sch Med, Dept Pediat, Tokyo 113, Japan Chiba Univ, Sch Med, Dept Pediat, Chiba 280, Japan Chiba Univ Chiba Japan 280 Univ, Sch Med, Dept Pediat, Chiba 280, Japan Chiba Childrens Hosp, Dept Hematol & Oncol, Chiba, Japan Chiba Childrens Hosp Chiba Japan sp, Dept Hematol & Oncol, Chiba, Japan Tokyo Metropolitan Kiyose Childrens Hosp, Dept Hematol, Tokyo, Japan TokyoMetropolitan Kiyose Childrens Hosp Tokyo Japan atol, Tokyo, Japan Tokyo Med & Dent Univ, Sch Med, Dept Pediat, Tokyo, Japan Tokyo Med & DentUniv Tokyo Japan v, Sch Med, Dept Pediat, Tokyo, Japan Gunma Univ, Sch Med, Dept Pediat, Maebashi, Gumma 371, Japan Gunma Univ Maebashi Gumma Japan 371 pt Pediat, Maebashi, Gumma 371, Japan Univ Tokyo, Fac Med, Dept Pediat, Tokyo, Japan Univ Tokyo Tokyo JapanUniv Tokyo, Fac Med, Dept Pediat, Tokyo, Japan Tokai Univ, Sch Med, Dept Pediat, Isehara, Kanagawa 25911, Japan Tokai Univ Isehara Kanagawa Japan 25911 t, Isehara, Kanagawa 25911, Japan Jikei Univ, Sch Med, Dept Pediat, Tokyo, Japan Jikei Univ Tokyo JapanJikei Univ, Sch Med, Dept Pediat, Tokyo, Japan Jikei Univ, Sch Med, Dept Blood Transfus, Tokyo, Japan Jikei Univ Tokyo Japan Univ, Sch Med, Dept Blood Transfus, Tokyo, Japan St Lukes Int Hosp, Dept Pediat, Tokyo, Japan St Lukes Int Hosp Tokyo Japan Lukes Int Hosp, Dept Pediat, Tokyo, Japan Natl Canc Ctr, Cent Hosp, Dept Pediat, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104 , Cent Hosp, Dept Pediat, Tokyo 104, Japan Kyorin Univ, Sch Med, Dept Pediat, Tokyo, Japan Kyorin Univ Tokyo JapanKyorin Univ, Sch Med, Dept Pediat, Tokyo, Japan Natl Childrens Hosp, Dept Hematol, Tokyo 154, Japan Natl Childrens Hosp Tokyo Japan 154 Hosp, Dept Hematol, Tokyo 154, Japan Natl Childrens Hosp, Dept Oncol, Tokyo 154, Japan Natl Childrens Hosp Tokyo Japan 154 s Hosp, Dept Oncol, Tokyo 154, Japan Toho Univ, Sch Med, Dept Pediat 1, Tokyo, Japan Toho Univ Tokyo JapanToho Univ, Sch Med, Dept Pediat 1, Tokyo, Japan Yamanashi Med Univ, Dept Pediat, Sch Med, Kofu, Yamanashi, Japan YamanashiMed Univ Kofu Yamanashi Japan Sch Med, Kofu, Yamanashi, Japan
Titolo Testata:
LEUKEMIA
fascicolo: 12, volume: 14, anno: 2000,
pagine: 2295 - 2306
SICI:
0887-6924(200012)14:12<2295:LFOCAL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPY; JAPAN;
Keywords:
childhood acute lymphoblastic leukemia; long-term follow-up; event-free survival; CNS relapse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuchida, M Ibaraki Childrens Hosp, Dept Pediat, 3-3-1 Futabadai, Mito, Ibaraki 3114145, Japan Ibaraki Childrens Hosp 3-3-1 Futabadai Mito Ibaraki Japan 3114145
Citazione:
M. Tsuchida et al., "Long-term follow-up of childhood acute lymphoblastic leukemia in Tokyo Children's Cancer Study Group 1981-1995", LEUKEMIA, 14(12), 2000, pp. 2295-2306

Abstract

The objectives were as follows: Firstly, to estimate the overall probability of event-free survival (EFS) and isolated CNS relapse in the studies forchildren with acute lymphoblastic leukemia (ALL) during the 1980s and 1990s. Secondly, to report the EFS according to presenting features and lineage. Thirdly, to evaluate the treatment results re-classified by the risks of NCI criteria. Four consecutive protocol studies were performed in the TokyoChildren's Cancer Study Group: L81-10 protocol (1981-1984, 189 patients), L84-11 (1984-1989, 484 patents), L89-12 (1989-1992 418 patients) and L92-13(1992-1995, 347 patients). Overall EFS at 5 years in each protocol was 56.5 +/- 3.8(1 s.e.)%, 71.0 +/- 2.1%, 67.8 +/- 2.3%, and 63.4 +/- 2.7%, respectively. The cumulative isolated CNS relapse rate at 5 years was 8.1 +/- 2.1%, 3.5 +/- 0.9%, 3.6 +/- 1.0%, 1.0 +/- 0.6. The EFS in SR/HR (standard risk/high risk) according to the NCI criteria in B-precursor ALL at 5 years was61.9 +/- 4.3%/41.4 +/- 7.4% (lineage was not confirmed.), 72.5 +/- 2.6%/63.4 +/- 5.0%, 77.4 +/- 2.7%/56.3 +/- 4.7%, and 67.8 +/- 3.4%/56.7 +/- 5.4% in each protocol. Also EFSs according to NCI SR/HR at 5 years of T-ALL in protocols L84-11, L89-12 and L92-13 were 55.6 +/- 16.6%/60.9 +/- 10.1%, 72.7 /- 13.4%/51.6 +/- 9.1%, and 77.1 +/- 14.4%/53.6/10.1%, respectively. The truncation of maintenance therapy to 6 months resulted in a decreased EFS inL92-13, particularly due to an increase of bone marrow relapse after cessation of therapy in SR and HR. The NCI risk criteria work properly even in the patients treated by different intensities, so that it makes the comparison possible among the patients in various groups. The overall EFSs in childhood ALL improved in 1980s, but it seemed stable or decreased in 1990s. Theshort maintenance therapy resulted in poor outcome in SR on the L92-13 protocol. Many of these late relapsers were effectively rescued and over-all survival remained at a high level. The proportion of patients who received cranial irradiation reduced without any increase of the CNS events.

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Documento generato il 20/01/20 alle ore 04:53:49