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Titolo:
Dissecting the pathways to death
Autore:
Daniel, PT;
Indirizzi:
Humboldt Univ, Dept Hematol Oncol & Tumor Immunol, Med Ctr Charite, D-13125 Berlin, Germany Humboldt Univ Berlin Germany D-13125 tr Charite, D-13125 Berlin, Germany
Titolo Testata:
LEUKEMIA
fascicolo: 12, volume: 14, anno: 2000,
pagine: 2035 - 2044
SICI:
0887-6924(200012)14:12<2035:DTPTD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; CYTOCHROME-C RELEASE; APOPTOTIC CELL-DEATH; ENDOPLASMIC-RETICULUM; LIGAND EXPRESSION; LYMPHOMA-CELLS; RETINOIC ACID; NB4 CELLS; LOW BAX; ACTIVATION;
Keywords:
apoptosis; programmed cell death; mitochondria; endoplasmic reticulum; death receptors; Bcl-2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Daniel, PT Humboldt Univ, Dept Hematol Oncol & Tumor Immunol, Med Ctr Charite, CampusBerlin Buch,Lindenberger Weg 80, D-13125 Berlin, Germany Humboldt Univ Campus Berlin Buch,Lindenberger Weg 80 Berlin Germany D-13125
Citazione:
P.T. Daniel, "Dissecting the pathways to death", LEUKEMIA, 14(12), 2000, pp. 2035-2044

Abstract

This report summarizes recent findings in the field of basic and translational apoptosis research which were presented at the 1st Conference on 'Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention' organized by the European School of Hematology and the University of Texas MD Anderson Cancer Center, 13-17 May, in Dublin, Ireland, and puts them in thecontext of the literature. Recent discoveries have significantly advanced the understanding of biochemical and genetic requirements of distinct apoptosis pathways (ie mitochondrial, death-receptor and endoplasmic reticulum-mediated apoptosis) and their dysregulation in disease. Progress has been made especially in the elucidation of the mechanisms of action of the Bcl-2 family members, in detail the formation of channels and their regulation in the mitochondrial membranes, conformational changes in Bax and Bak, and crosstalk of death receptor-triggered apoptosis to the mitochondria by activation of Bax via Bid. In addition, novel insights have been gained about the regulation of caspases and novel caspase signaling pathways, such as activation of caspase-12 by the endoplasmic reticulum stress response. Therapeutic applications of apoptosis manipulation include (1) the inhibition of caspases in acute and chronic neurodegenerative diseases, ie stroke, Alzheimer's or Huntington's disease by drugs and (2) sensitization of cancer cells for drug/radiation-induced apoptosis by modulation of survival signals and viral transfer of apoptosis promoting genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 23:52:24