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Titolo:
Blockade of NMDA receptors in the amygdala prevents latent inhibition of fear-conditioning
Autore:
Schauz, C; Koch, M;
Indirizzi:
Univ Bremen, Brain Res Inst, D-28334 Bremen, Germany Univ Bremen Bremen Germany D-28334 ain Res Inst, D-28334 Bremen, Germany Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany
Titolo Testata:
LEARNING & MEMORY
fascicolo: 6, volume: 7, anno: 2000,
pagine: 393 - 399
SICI:
1072-0502(200011/12)7:6<393:BONRIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIATED STARTLE PARADIGM; BASOLATERAL AMYGDALA; STIMULUS PREEXPOSURE; RETROGRADE-AMNESIA; TEMPORAL GRADIENT; VISUAL PATHWAY; SCHIZOPHRENIA; THALAMUS; MEMORY; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Koch, M Univ Bremen, Brain Res Inst, D-28334 Bremen, Germany Univ Bremen Bremen Germany D-28334 Inst, D-28334 Bremen, Germany
Citazione:
C. Schauz e M. Koch, "Blockade of NMDA receptors in the amygdala prevents latent inhibition of fear-conditioning", LEARN MEM, 7(6), 2000, pp. 393-399

Abstract

The association between a conditioned stimulus (CS) and an unconditioned stimulus (US) in fear-conditioning depends on N-methyl-D-aspartate (MMDA) receptors in the basolateral amygdala complex (BLA). Latent inhibition (LI) is the retardation in learning due to nonreinforced presentation of the prospective CS before conditioning. Disruption of LI in rats is an animal modelof schizophrenia, reflecting the deficits of schizophrenic patients in neglecting irrelevant information. We investigated whether the BLA is involvedin LI of fear-potentiated startle. Infusions of the NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (AP-5; 12.5 nmoles) into the BLA before preexposure of rats to the neutral stimulus prevent LI of fear-conditioning. We also demonstrated by the same method that a complex of thalamic nuclei, comprising the medial part of the medial geniculate nucleus, the posterior intralaminar nucleus, and the suprageniculate nucleus, is involved in fear-conditioning, but not in LI. This suggests that the presentation ofan innocuous stimulus during preexposure leads to an NMDA receptor-dependent change of neurotransmission in the BLA, but not in the thalamus. Our data show that the BLA but not the thalamus regulates in LI of fear-potentiated startle. Furthermore, it supports the hypothesis that the inability of schizophrenic patients to ignore irrelevant stimuli may be caused by hypofunction of the glutamatergic transmission in the brain and suggests an involvement of the amygdala in the neuropathology of schizophrenia.

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Documento generato il 07/04/20 alle ore 22:23:22