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Titolo:
Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats
Autore:
Katafuchi, T; Li, AJ; Hirota, S; Kitamura, Y; Hori, T;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Integrat Physiol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 tegrat Physiol, Fukuoka 8128582, Japan Osaka Univ, Grad Sch Med, Dept Pathol, Suita, Osaka 565, Japan Osaka UnivSuita Osaka Japan 565 ed, Dept Pathol, Suita, Osaka 565, Japan
Titolo Testata:
LEARNING & MEMORY
fascicolo: 6, volume: 7, anno: 2000,
pagine: 383 - 392
SICI:
1072-0502(200011/12)7:6<383:IOSLAH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; STEM-CELL-FACTOR; PAIRED-PULSE FACILITATION; TYROSINE KINASE RECEPTOR; CULTURED MAST-CELLS; GROWTH-FACTOR; SI-LOCUS; ARACHIDONIC-ACID; CA2+ CHANNELS; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Katafuchi, T Kyushu Univ, Grad Sch Med Sci, Dept Integrat Physiol, Fukuoka8128582, Japan Kyushu Univ Fukuoka Japan 8128582 l, Fukuoka 8128582, Japan
Citazione:
T. Katafuchi et al., "Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats", LEARN MEM, 7(6), 2000, pp. 383-392

Abstract

The c-kit receptor tyrosine kinase encoded by the white-spotting (W) gene is highly expressed in rat hippocampal CA1-CA4 regions. We found an impaired spatial learning and memory in homozygous c-kit (Ws/Ws) mutant rats that have a 12-base deletion in the tyrosine kinase domain of the c-kit gene anda very low kinase activity. Electrophysiological studies in hippocampal slices revealed that the long-term potentiation (LTP) induced by the tetanic stimulation (100 Hz, 1 sec) in the mossy fiber (NIF)-CA3 pathway, but not in the Schaffer collaterals/commissural-CA1 pathway, was significantly reduced in c-kit mutants compared with wild-type (+/+) rats. The paired-pulse facilitation (PPF) was measured before the tetanus and after the establishment of the LTP in each slice. The initial PPF in the MF-CA3 pathway positively correlated with the amplitude of the LTP in the wild-type rats but not inthe c-kit mutant rats. Furthermore, they failed to show the normal characteristics observed in the MF-CA3 pathway of +/+ rats; that is, the negative correlation between the initial PPF and the changes in PPF measured after the LTP. These findings suggest an involvement of SCF/c-kit signaling in hippocampal synaptic potentiation and spatial learning and memory.

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Documento generato il 04/04/20 alle ore 23:55:47