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Titolo:
Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice
Autore:
Tognoni, G; Avanzini, F; Pangrazzi, J; Roncaglioni, MC; Bertele, V; de Gaetano, G; Caimi, V; Tombesi, M; Colombo, F; Barlera, S; Clerici, F; Palumbo, A; Sgaroni, G; Geraci, E; Del Favero, A; Decarli, A; Alli, C; Beghi, E; Coen, D; Volpi, A; Accattoli, P; Agneta, A; Alberino, S; Amoroso, U; Angeletti, M; Antiga, G; Ariutti, R; Armani, F; Bacci, G; Balzan, C; Banchi, G; Barba, G; Baron, P; Barone, A; Bartoli, M; Bartoli, PL; Barucca, G; Bedon, R; Bellini, M; Bencivenni, A; Benetti, R; Beretta, E; Bertini, L; Bertolissi, S; Berton, G; Besozzi, E; Bevilacqua, S; Bianchi, A; Bigotto, D; Bini, MI; Bizzarri, G; Boldini, L; Pioltelli, MB; Bossi, S; Bozzetto, RM; Brizzi, A; Bruno, B; Bussotti, A; Buzzatti, A; Cadioli, T; Caimi, V; Calciano, FP; Caldarini, L; Calienno, S; Caltaginone, P; Cancian, M; Cantamessa, GL; Caporali, N; Carli, M; Cascini, G; Casella, P; Casella, M; Caso, C; Cassanelli, M; Catalano, A; Cavallini, M; Cazzaniga, F; Cedaro, P; Celia, M; Cella, L; Chiara, P; Ciardullo, AV; Ciccone, G; Ciociano, C; Cipolla, A; Ciprietti, E; Cocco, L; Cocconi, F; Conio, S; Corasaniti, F; Cozzani, L; Cressotti, ML; Cuozzo, E; Cusmai, L; DErrico, GB; DInnocente, G; De Angelis, C; De Chirico, C; De Grandi, M; De Maria, E; De Matteis, C; De Matteis, D; Della Vedova, R; Di Giovambattista, E; Di Giuseppe, M; Di Santi, M; Dionette, MG; Egitto, A; Emma, V; Ermacora, T; Esposito, P; Falcoz, M; Civitillo, UF; Ferrara, FN; Ferrari, V; Ferreri, A; Ferroni, M; Filippo, S; Fortunato, S; Fossati, B; Frapporti, G; Frascati, A; Fucili, R; Fumagalli, MA; Gadducci, P; Galli, G; Galvani, O; Gamerini, V; Gangi, F; Gasparri, R; Gazzetta, F; Gentile, W; Germano, S; Germini, F; Ghionda, F; Giaretta, M; Giommoni, U; Giugliano, R; Giusta, F; Giusti, P; Grilli, P; Groppelli, G; Gualtieri, S; Guerrini, A; Guillaro, B; Ibello, L; Ingletti, MA; Klavora, MG; Lattuada, G; Lauri, D; Lenotti, M; Lepore, L; Licursi, G; Lombardi, P; Lombardo, M; Lorello, M; Lovisa, E; Luisetto, G; Luvisi, P; Maestri, P; Maggioni, R; Malavasi, P; Mao, M; Marcello, A; Marinacci, S; Marini, E; Marolla, M; Martini, C; Marulli, C; Masperi, M; Mastella, M; Mastrocola, M; Matteucci, A; Mazzu, M; Mellace, A; Mezzacapo, GM; Migaldi, D; Miluzio, A; Miradoli, R; Misiani, V; Monina, M; Montanari, U; Moretti, S; Morini, M; Moro, A; Moscardini, S; Moschitta, P; Mossa, V; Mureddu, G; Murgia, R; Mussini, AM; Nafra, G; Nasorri, R; Nati, G; Nicoletti, L; Nicoli, S; Nuccioni, S; Paci, C; Pagliani, S; Palatella, A; Palmieri, E; Panarese, G; Panigada, M; Panza, EG; Parma, E; Paroli, G; Patricelli, R; Perego, GB; Perrone, G; Perugini, I; Petracchini, V; Petrera, L; Petrucci, R; Piazza, G; Piccolo, F; Pignatti, M; Pignotti, DE; Pinto, D; Pirovano, E; Pirrotta, D; Pizzolon, F; Poggi, D; Prencipe, G; Quinterio, S; Rafanelli, P; Ragone, L; Ramunni, A; Ribetto, BM; Rinaldi, N; Riva, MG; Rocca, M; Rossitto, A; Sagnelli, C; Saitta, G; Salvi, S; Salvio, G; Sampaolo, G; Santangelo, A; Shianchi, P; Schirosa, G; Schirra, A; Scolarin, C; Serni, R; Serra, O; Seveso, MP; Silvestre, G; Simone, C; Simonetti, R; Sissa, F; Sizzano, E; Soave, P; Staffilano, N; Stranges, M; Suzzi, F; Suzzi, M; Tazza, AC; Telleschi, D; Titta, G; Tognolo, M; Tomasi, A; Tomba, A; Tombesi, M; Tonello, P; Tonon, R; Torella, M; Tornari, P; Uberti, M; Ursini, G; Varriale, A; Vece, R; Ventriglia, R; Venturini, O; Veramonti, I; Veronelli, G; Verrengia, L; Villa, A; Villa, F; Vincenti, G; Visca, MR; Visona, E; Vitali, F; Vitanza, A; Zappone, P; Zorzetti, G; Autoliatano, A; Artusa, M; Berto, I; Bajardi, P; Beretta, R; Costantini, C; Caldorola, P; Barile, N; Cavalera, C; Cristofari, M; DAmico, S; Fiorenza, AM; Torri, A; Garavelli, G; Giardinieri, M; Nosotti, L; Guglielmi, M; Pietrofeso, R; Mattarei, M; Rossi, S; Pasotti, C; Capra, A; Ronchi, E; Palumbo, G; Stagni, B; Cappellari, G; Faronato, PP; Lagomanzini, P; Capuano, V; Castiglioni, G; Fantasia, R; Cosmi, F; De Vivo, L; De Caro, G; Pepe, G; Di Mauro, G; Gifuni, FE; Magliaro, A; Muzio, F; Piantadosi, FR; Scarlini, GF; DAguanno, G; Sodano, G; Vicari, L; Roncaglioni, MC; Avanzini, F; Colombo, F; Pangrazzi, J; Tognoni, G; Bertele, V; de Goetsme, G; Caimi, V; Tombesi, M;
Indirizzi:
Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy Consorzio Mario NegriSud Santa Maria Imbaro Italy Maria Imbaro, Italy Ctr Studi & Ric Med Gen, Monza, Italy Ctr Studi & Ric Med Gen Monza Italy r Studi & Ric Med Gen, Monza, Italy
Titolo Testata:
LANCET
fascicolo: 9250, volume: 357, anno: 2001,
pagine: 89 - 95
SICI:
0140-6736(20010113)357:9250<89:LAAVEI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; CLINICAL-TRIALS; E CONSUMPTION; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Roncaglioni, MC Mario Negri Inst Pharmacol Res, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
G. Tognoni et al., "Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice", LANCET, 357(9250), 2001, pp. 89-95

Abstract

Background In addition to the treatment of specific cardiovascular risk factors, intervention which interferes with the general mechanisms of atherosclerosis could further reduce the incidence of cardiovascular events. We aimed to investigate in general practice the efficacy of antiplatelets and antioxidants in primary prevention of cardiovascular events in people with one or more major cardiovascular risk factors. Methods We did a randomised controlled open 2x2 factorial trial to investigate low-dose aspirin (100 mg/day) and vitamin E (300 mg/day) in the prevention of cardiovascular events, in people with one or more of the following:hypertension, hypercholesterolaemia, diabetes, obesity, family history of premature myocardial infarction, or individuals who were elderly. Findings 4495 people (2583 female, mean age 64.4 years) were included in the trial. After a mean follow-up of 3.6 years the trial was prematurely stopped on ethical grounds when newly available evidence from other trials on the benefit of aspirin in primary prevention was strictly consistent with the results of the second planned interim analysis. Aspirin lowered the frequency of all the endpoints, being significant for cardiovascular death (from 1.4 to 0.8%; relative risk 0.56 [95% CI 0.31-0.99]) and total cardiovascular events (from 8.2 to 6.3%; 0.77 [0.62-0.95]). Severe bleedings were morefrequent in the aspirin group than the no-aspirin group (1.1% vs 0.3%; p<0.0008). Vitamin E showed no effect on any prespecified endpoint. Analyses were by intention-to-treat. p<0.0008). Interpretation In women and men at risk of having a cardiovascular event because of the presence of at least one major risk factor, law-dose aspirin given in addition to treatment of specific risk factors contributes an additional preventive effect, with an acceptable safety profile. The results onvitamin E's cardiovascular primary preventive efficacy are not conclusive per se, although our results are consistent with the negative results of other large published trials on secondary prevention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 04:28:55