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Titolo:
Effect of lipid reduction on the progression of renal disease: A meta-analysis
Autore:
Fried, LF; Orchard, TJ; Kasiske, BL;
Indirizzi:
Univ Pittsburgh, Sch Med, Renal Electrolyte Div, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 yte Div, Pittsburgh, PA 15213 USA VA Pittsburgh Healthcare Syst, Med Serv, Renal Sect, Pittsburgh, PA USA VAPittsburgh Healthcare Syst Pittsburgh PA USA Sect, Pittsburgh, PA USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA th, Dept Epidemiol, Pittsburgh, PA USA Hennepin Cty Med Ctr, Dept Med, Div Nephrol, Minneapolis, MN 55415 USA Hennepin Cty Med Ctr Minneapolis MN USA 55415 , Minneapolis, MN 55415 USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 1, volume: 59, anno: 2001,
pagine: 260 - 269
SICI:
0085-2538(200101)59:1<260:EOLROT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL-LOWERING THERAPY; DEPENDENT DIABETES-MELLITUS; DIETARY-PROTEIN RESTRICTION; REDUCES GLOMERULAR INJURY; SIMVASTATIN TREATMENT; NEPHROTIC SYNDROME; LONG-TERM; HYPERCHOLESTEROLEMIC PATIENTS; URINE SAMPLES; HUMAN-KIDNEY;
Keywords:
hyperlipidemia; nephropathy; progressive renal disease; proteinuria; albuminuria; glomerular filtration rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Fried, LF Univ Pittsburgh, Sch Med, Renal Electrolyte Div, 938 Scaife Hall,3550 Terrace St, Pittsburgh, PA 15213 USA Univ Pittsburgh 938 Scaife Hall,3550 Terrace St Pittsburgh PA USA 15213
Citazione:
L.F. Fried et al., "Effect of lipid reduction on the progression of renal disease: A meta-analysis", KIDNEY INT, 59(1), 2001, pp. 260-269

Abstract

Background. It has been proposed that hyperlipidemia contributes to the progression of renal disease. A large trial has not been performed; however, a number of small, controlled trials have been reported. We examined the effects of antilipemic agents on glomerular filtration rate and proteinuria or albuminuria in patients with renal disease. Methods. We used Medline, abstracts from scientific meetings, and bibliographies from recent reviews and scientific reports to locate pertinent studies. Thirteen prospective con trolled trials examining the effects of antilipemic agents on renal function, proteinuria, or albuminuria were included. Studies were published as full reports or abstracts and were at least threemonths in duration. For five of the studies, individual patient data were obtained. Other summary data were independently extracted from the published reports by two investigators and included study quality, subject characteristics, cause of renal disease, change in serum cholesterol, blood pressure, glomerular filtration rate, proteinuria, and albuminuria. Results. There was a lower rate of decline in glomerular filtration rate with treatment compared with controls (treated controls, 0.156 mL/min/month;95% CI, 0.026 to 0.285 mL/ min/month, P = 0.008). The study results were statistically homogeneous, and in a regression analysis, the effect of treatment on glomerular filtration rate did not correlate with study quality, the percentage change in cholesterol, the type of lipid-lowering agent, or the cause of renal disease. However, longer follow-up correlated with the amount of improvement in glomerular filtration rate from treatment (P = 0.007). There was a tendency for a favorable effect of treatment on protein or albumin excretion [Ln (treatment) - Ln (control) = -0.248, 95% CI, -0.562 to 0.064, P = 0.077]. However, these results were statistically heterogeneous between studies (P < 0.001). No obvious explanation for this heterogeneity was apparent in a regression analysis examining potential reasons for differences in study results. Conclusions. Lipid reduction may preserve glomerular filtration rate and may decrease proteinuria in patients with renal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:22:14