Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clusterin is up-regulated in glomerular mesangial cells in complement-mediated injury
Autore:
Yamada, K; Hori, Y; Hanafusa, N; Okuda, T; Nagano, N; Choi-Miura, NH; Couser, WG; Miyata, T; Kurokawa, K; Fujita, T; Nangaku, M;
Indirizzi:
Univ Tokyo, Sch Med, Dept Internal Med, Div Nephrol & Endocrinol,Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ndocrinol,Bunkyo Ku, Tokyo 1130033, Japan Kirin Brewery Co Ltd, Pharmaceut Res Lab, Takasaki, Gumma, Japan Kirin Brewery Co Ltd Takasaki Gumma Japan es Lab, Takasaki, Gumma, Japan Showa Univ, Sch Pharmaceut Sci, Dept Physiol Chem, Tokyo 142, Japan Showa Univ Tokyo Japan 142 ceut Sci, Dept Physiol Chem, Tokyo 142, Japan Tokai Univ, Sch Med, Kanagawa 2591100, Japan Tokai Univ Kanagawa Japan 2591100 Univ, Sch Med, Kanagawa 2591100, Japan Univ Washington, Div Nephrol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Div Nephrol, Seattle, WA 98195 USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 1, volume: 59, anno: 2001,
pagine: 137 - 146
SICI:
0085-2538(200101)59:1<137:CIUIGM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRAL PROSTATE; EXPERIMENTAL MEMBRANOUS NEPHROPATHY; GLOMERULONEPHRITIS TYPE-II; PASSIVE HEYMANN NEPHRITIS; MESSENGER-RNA; GENE-EXPRESSION; SULFATED GLYCOPROTEIN-2; RENAL INJURY; CHROMAFFIN GRANULES; APOLIPOPROTEIN-J;
Keywords:
apoptosis; OX-7; C5b-9; anti-Thy1 nephritis; membranous nephropathy; tissue injury; serum protein 40,40; membrane attack complex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Nangaku, M Univ Tokyo, Sch Med, Dept Internal Med, Div Nephrol & Endocrinol,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 okyo 1130033, Japan
Citazione:
K. Yamada et al., "Clusterin is up-regulated in glomerular mesangial cells in complement-mediated injury", KIDNEY INT, 59(1), 2001, pp. 137-146

Abstract

Background. Clusterin is a soluble complement regulatory protein that binds to C5b-7 and inhibits generation of membrane attack complex, C5b-9. Glomerular deposition of clusterin has been observed in human and experimental membranous nephropathy in association with C5b-9 and immune deposits. However, it is controversial as to whether clusterin observed in glomeruli is synthesized by the resident glomerular cells or is derived from the circulation. We examined whether clusterin is expressed by resident glomerular cells exposed to complement-mediated injury. Methods. In vitro, cultured mesangial cells were exposed to antithymocyte serum immunoglobulin G and 5% normal rat serum as a complement source. In vivo, we induced anti-TTy1 nephritis in rats and examined the kidneys on days 8 and 29. Results. We observed increased expression of clusterin in cultured rat glomerular mesangial cells stimulated by sublytic complement attack. We also demonstrated that in comparison with control rats, both a marked increase inclusterin mRNA in the glomeruli and marked deposition of clusterin proteinin the mesangial area occurred in the OX-7-treated rats on day 8 in association with C5b-9 deposition and on day 29. Conclusion. Clusterin was induced in glomerular mesangial cells during thecourse of immune-mediated injuries. This upregulation of clusterin may play a critical role in protecting mesangial cells from complement attack.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 22:52:15