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Titolo:
Regulation of renal tubular secretion of organic compounds
Autore:
Berkhin, EB; Humphreys, MH;
Indirizzi:
Univ Calif San Francisco, SFGH, Div Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 1, volume: 59, anno: 2001,
pagine: 17 - 30
SICI:
0085-2538(200101)59:1<17:RORTSO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARA-AMINOHIPPURATE TRANSPORT; MEDIATING BASOLATERAL UPTAKE; KIDNEY PROXIMAL TUBULES; EPITHELIAL-CELL LINE; PROTEIN-KINASE-C; ANION TRANSPORTER; CATION TRANSPORTER; RAT-KIDNEY; FUNCTIONAL-CHARACTERIZATION; MULTIDRUG TRANSPORTER;
Keywords:
anion and cation transport; cellular transporters; neural control; cardiac glycosides; diuretics; protein synthesis; antineoplastic agents; immunomodulators;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Humphreys, MH Univ Calif San Francisco, SFGH, Div Neurol, Box 1341, San Francisco, CA 94143 USA Univ Calif San Francisco Box 1341 San Francisco CA USA 94143
Citazione:
E.B. Berkhin e M.H. Humphreys, "Regulation of renal tubular secretion of organic compounds", KIDNEY INT, 59(1), 2001, pp. 17-30

Abstract

Background. Information on the molecular basis underlying organic anion and cation transport in renal tubules has expanded in recent years with the identification and characterization of numerous transporters. However, little is known about the regulation of this transport. Methods. Both English and Russian language studies dealing with the regulation of organic ion transport by the kidney have been reviewed. Results. This review summarizes the literature on the physiological and pharmacological aspects of the regulation of organic ion transport, linking this information where possible to underlying transport mechanisms. Current models of the tubular secretion of organic anions and cations are reviewed. Factors that inhibit or enhance tubular secretion of xenobiotics are described, and their influence on proximal tubule cell transport and function isdiscussed. Important roles for substrate stimulation, the adrenergic nervous system, numerous hormones, P-glycoprotein, and protein kinase C activityhave been identified. Conclusions. Despite considerable advances in the understanding of basic transport pathways and mechanisms involved in the tubular secretion of organic compounds, there is still relatively little information on the regulation of this transport. Studies combining the techniques of integrative and cell physiology and molecular biology will provide significant new insights into the pathways regulating the tubular transport of these compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:13:52