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Titolo:
Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population
Autore:
Anisimov, SV; Volkova, MV; Lenskaya, LV; Khavinson, VK; Solovieva, DV; Schwartz, EI;
Indirizzi:
IP Pavlov St Petersburg State Med Univ, Dept Cardiol, St Petersburg, Russia IP Pavlov St Petersburg State Med Univ St Petersburg Russia urg, Russia RAS, St Petersburg Inst Nucl Phys, Lab Human Mol Genet, Gatchina, Russia RAS Gatchina Russia st Nucl Phys, Lab Human Mol Genet, Gatchina, Russia City Geriatr Ctr, St Petersburg, Russia City Geriatr Ctr St Petersburg Russia eriatr Ctr, St Petersburg, Russia St Petersburg Inst Bioregulat & Gerontol, St Petersburg, Russia St Petersburg Inst Bioregulat & Gerontol St Petersburg Russia g, Russia
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 1, volume: 56, anno: 2001,
pagine: B27 - B32
SICI:
1079-5006(200101)56:1<B27:AAOTAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RESPONSE ELEMENT; CORONARY HEART-DISEASE; LIPOPROTEIN-LIPASE; TRANSGENIC MICE; HYPERTRIGLYCERIDEMIA; EXPRESSION; RESISTANCE; PROMOTER; LONGEVITY; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Anisimov, SV NIA, Cardiovasc Sci Lab, Ctr Gerontol Res, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA NIA 5600 Nathan Shock Dr Baltimore MD USA 21224 MD 21224 USA
Citazione:
S.V. Anisimov et al., "Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population", J GERONT A, 56(1), 2001, pp. B27-B32

Abstract

Apolipoprotein C-III (apoC-III) is the major component of triglyceride-rich lipoproteins. One of six identified polymorphisms in the apoC-III 5'-untranslated region (T-455C) is located within a functional insulin-response element. In a group of 137 elderly individuals (70-106 gears old), the alleledistribution was analyzed using restriction fragment length polymorphisms. Statistical analysis of allele frequencies was performed on subgroups selected by age and in elderly patients with arterial hypertension or ischemic heart disease. A greater frequency of the apoC-III -455C allele was demonstrated with aging ( p.005). No statistically significant difference in allele distributions was detected between healthy subjects and groups of elderlypatients of the same age with either ischemic heart disease or arterial hypertension. The increased incidence of the C allele with advanced age indicates that this variant promoter is associated with longevity. The greater incidence of this allele is detectable only in adults older than 80 years ofage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:59:05