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Titolo:
Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men
Autore:
Tadamura, E; Iida, H; Matsumoto, K; Mamede, M; Kubo, S; Toyoda, H; Shiozaki, T; Mukai, T; Magata, Y; Konishi, J;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Nucl Med & Diagnost Imaging, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 t Imaging, Sakyo Ku, Kyoto 6068507, Japan Natl Cardiovasc Ctr, Dept Radiol, Suita, Osaka 565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 565 Radiol, Suita, Osaka 565, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 1, volume: 37, anno: 2001,
pagine: 130 - 136
SICI:
0735-1097(200101)37:1<130:COMBFD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; POSITRON-EMISSION-TOMOGRAPHY; ST-SEGMENT DEPRESSION; STRESS ECHOCARDIOGRAPHY; N-13 AMMONIA; PERFUSION SCINTIGRAPHY; RISK STRATIFICATION; MULTICENTER-TRIAL; CARDIAC EVENTS; YOUNG MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Tadamura, E Kyoto Univ, Grad Sch Med, Dept Nucl Med & Diagnost Imaging, Sakyo Ku, 54 Shogoinkawahara, Kyoto 6068507, Japan Kyoto Univ 54 Shogoinkawahara Kyoto Japan 6068507 8507, Japan
Citazione:
E. Tadamura et al., "Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men", J AM COL C, 37(1), 2001, pp. 130-136

Abstract

OBJECTIVES The present study was designed to compare the absolute myocardial blood flow (MBF) after intravenous dipyridamole infusion with that during dobutamine-atropine administration in normal healthy male volunteers. BACKGROUND Both safety and usefulness of dobutamine-atropine stress in myocardial perfusion imaging have been reported. However, no information exists on whether the magnitude of hyperemia achieved with dipyridamole and dobutamine-atropine is comparable. METHODS Myocardial blood flow was measured with positron emission tomography and O-15-labeled water in 20 healthy young men (23 +/- 3 years) 1) at baseline, 2) after dipyridamole infusion (0.56 mg/kg over 4 min), and 3) during dobutamine (40 mug/kg/min) and atropine (0.25 to 1.0 mg) infusion. RESULTS The MBF was significantly increased during dipyridamole infusion and during dobutamine-atropine stress compared with at rest (4.33 +/- 1.23 and 5.89 +/- 1.58 vs. 0.67 +/- 0.16 ml/min/g, respectively, p < 0.0001). Moreover, dobutamine-atropine infusion produced greater MBF compared with dipyridamole (p = 0.0011), while coronary vascular resistance did not differ significantly after dipyridamole administration and during dobutamine-atropine infusion (17.6 +/- 7.9 vs. 18.6 +/- 5.6 mm Hg/[ml/min/g], respectively). CONCLUSIONS Near maximal coronary vasodilatation caused by dipyridamole isattainable using dobutamine and atropine in young healthy volunteers. Dobutamine in conjunction with atropine is no less effective than dipyridamole in producing myocardial hyperemia. (J Am Cell Cardiol 2001;37: 130-6) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:51:24