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Titolo:
Expression of apoptosis markers on peripheral blood lymphocytes from patients with cutaneous T-cell lymphoma during extracorporeal photochemotherapy
Autore:
Osella-Abate, S; Zaccagna, A; Savoia, P; Quaglino, P; Salomone, B; Bernengo, MG;
Indirizzi:
Univ Turin, Dermatol Clin 1, Dept Med & Surg Specialties, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 & Surg Specialties, I-10126 Turin, Italy
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
fascicolo: 1, volume: 44, anno: 2001,
pagine: 40 - 47
SICI:
0190-9622(200101)44:1<40:EOAMOP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTODYNAMIC THERAPY; SEZARY-SYNDROME; DIFFERENTIAL EXPRESSION; ULTRAVIOLET-A; FAS ANTIGEN; BCL-2; PHOTOPHERESIS; DEATH; MONOCYTES; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bernengo, MG Univ Turin, Dermatol Clin 1, Dept Med & Surg Specialties, V Cherasco 23, I-10126 Turin, Italy Univ Turin V Cherasco 23 Turin Italy I-10126 26 Turin, Italy
Citazione:
S. Osella-Abate et al., "Expression of apoptosis markers on peripheral blood lymphocytes from patients with cutaneous T-cell lymphoma during extracorporeal photochemotherapy", J AM ACAD D, 44(1), 2001, pp. 40-47

Abstract

The mechanisms of extracorporeal photochemotherapy (ExP) therapeutic activity in cutaneous T-cell lymphomas (CTCLs) are not yet well understood, eventhough it has been suggested that a major mechanism ma) be induction of apoptosis. In vitro studies demonstrate that UVA-induced apoptosis is mediated by CD95-Fas expression and inhibited by Bcl-2 up-regulation and that UVA irradiation is able to down-regulate Bcl-2 expression. High-resolution multiparameter flow-cytometric analyses were used tc, evaluate Bcl-2/CD95-Fas expression on phenotypically identifiable circulating clonal T cells from 7 patients with CTCL (4 with Sezary syndrome and 3 with mycosis fungoides with peripheral involvement) before and during ExP in an attempt to ascertain whether Bcl-2/CD95-Fas status can be related to the hematologic response. ABcl-2 normal phenotype before ExP or a normalization in Bcl-2 expression during ExP were related to a better clinical response, whereas a persistent Bcl-2 high expression was a negative prognostic factor. On the other hand, no response was found in patients with a CD95-Fas-negative phenotype, whereas the expression of CD95-Fas was associated with hematologic remission. Although further studies are needed to confirm these preliminary results, this study suggests that Bcl-2 and CD95-Fas expression could be evaluated, together with the other known clinical and immunologic factors, as additional parameters related to clinical response in patients with CTCL undergoing ExP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:05:48