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Titolo:
Effects of pentagastrin and the cold presser test on the acoustic startle response and pupillary function in man
Autore:
Tavernor, SJ; Abduljawad, KAJ; Langley, RW; Bradshaw, CM; Szabadi, E;
Indirizzi:
Univ Nottingham, Sch Med,Queens Med Ctr, Div Psychiat, Psychopharmacol Sect, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH, Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 14, anno: 2000,
pagine: 387 - 394
SICI:
0269-8811(2000)14:4<387:EOPATC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; INHIBITED LIGHT REFLEX; PANIC DISORDER; AGONIST PENTAGASTRIN; CHOLECYSTOKININ-TETRAPEPTIDE; ANXIETY; DIAZEPAM; HUMANS; SENSITIVITY; ACTIVATION;
Keywords:
anxiety; cold presser test; panic; pentagastrin; pupil; startle reflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tavernor, SJ Univ Nottingham, Sch Med,Queens Med Ctr, Div Psychiat, Psychopharmacol Sect, Room B109, Nottingham NG7 2UH, England Univ Nottingham RoomB109 Nottingham England NG7 2UH England
Citazione:
S.J. Tavernor et al., "Effects of pentagastrin and the cold presser test on the acoustic startle response and pupillary function in man", J PSYCHOPH, 14(4), 2000, pp. 387-394

Abstract

Pentagastrin, a cholecystokinin(2) (CCK2) receptor agonist, evokes autonomic and subjective features of anxiety in healthy volunteers. The present experiments examined the effects of pentagastrin on two responses with known sensitivity to another anxiogenic procedure (threat of electric shock): theacoustic startle response and the pupillary light reflex. The effects of pentagastrin were compared with those of the cold presser test, a procedure known to elicit sympathetic activation. Twelve healthy males (18-35 years) participated in two experiments each consisting of two sessions in which they received (1) pentagastrin (0.3 mug/kg, i.v.) and a control infusion (saline), and (2) cold presser test (90 s hand immersion at 4 degreesC) and a control immersion (37 degreesC), using a balanced single-blind protocol, Electromyographic responses of the orbicularis oculi to 40 ms, 1 kHz, 115 dB tones ('startle responses') [Experiment 1], and miotic responses to 200 ms, 0.43 mW/cm(2) light pulses [Experiment 2] were recorded before, during and after the infusions and hand immersions. Heart rate, blood pressure and subjective feelings were also recorded. The amplitude of the startle response was not significantly affected by pentagastrin, but was reduced during the cold presser test. Resting pupil diameter increased during both pentagastrin infusion and the cold presser test, but neither procedure altered the amplitude of the light reflex. Tachycardia, increased blood pressure and subjective anxiety were induced by both pentagastrin and the cold presser test, The cardiovascular and mydriatic effects of pentagastrin and the cold presser test are consistent with the known ability of these treatments to inducesympathetic activation. The anxiety induced by these treatments, unlike anxiety induced by threat of electric shock, was not accompanied by potentiation of the startle response or reduction of the miotic response. The results indicate that different anxiogenic procedures do not have equivalent effects on these reflexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:16:27