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Titolo:
Individual differences in mood reactions to d-amphetamine: a test of threepersonality factors
Autore:
Corr, PJ; Kumari, V;
Indirizzi:
Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England Univ London Goldsmiths Coll London England SE14 6NW on SE14 6NW, England Univ London, Inst Psychiat, Div Psychol Med, Sect Cognit Psychopharmacol, London, England Univ London London England Sect Cognit Psychopharmacol, London, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 14, anno: 2000,
pagine: 371 - 377
SICI:
0269-8811(2000)14:4<371:IDIMRT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR GENE; LATENT INHIBITION; NOVELTY SEEKING; SENSATION SEEKING; EXTROVERSION; ASSOCIATION; MECHANISMS; AROUSAL; ALLELES; HUMANS;
Keywords:
amphetamine; extraversion; individual differences; mood; novelty seeking; paradoxical effects; psychosis-proneness; psychoticism; substance abuse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Corr, PJ Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England Univ London Goldsmiths Coll London England SE14 6NW NW, England
Citazione:
P.J. Corr e V. Kumari, "Individual differences in mood reactions to d-amphetamine: a test of threepersonality factors", J PSYCHOPH, 14(4), 2000, pp. 371-377

Abstract

Individual differences in self-reported mood following either 5 mg or 10 mg d-amphetamine challenge were examined in order to test the modifying roleof three factors of personality, viz., the Eysencks' psychoticism, Cloninger's novelty seeking, and Depue and Collins' extraversion. In a double-blind study, mood measures (energetic arousal, tense arousal, and hedonic tone)were taken immediately following a single-dose of d-amphetamine and then again after 90 min. The results showed significant psychoticism x d-amphetamine interactions for both drug doses: d-amphetamine increased energetic arousal and hedonic tone, and reduced tense arousal, only in low psychoticism individuals; in high psychoticism individuals, it led to lowered energetic arousal and hedonic tone, and increased tense arousal. Neither novelty seeking nor extraversion modified the effects of d-amphetamine. These data suggest a link between psychoticism and dopaminergic functioning, although theydo not rule out the involvement of other transmitter systems (e.g. noradrenergic), In common with other studies, such findings point to the importantrole that well-established factors of personality play in accounting for individual differences in reactions to psychoactive drugs. It is concluded that the routine inclusion of personality measures in future psychopharmacological studies may help to refine the characterization of drug effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:16:02