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Titolo:
Increased expression of galectin-I in carcinoma-associated stroma predictspoor outcome in prostate carcinoma patients
Autore:
van den Brule, FA; Waltregny, D; Castronovo, V;
Indirizzi:
Univ Liege Hosp, Metastasis Res Lab, B-4000 Liege 1, Belgium Univ Liege Hosp Liege Belgium 1 astasis Res Lab, B-4000 Liege 1, Belgium
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 193, anno: 2001,
pagine: 80 - 87
SICI:
0022-3417(200101)193:1<80:IEOGIC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSIDE-BINDING PROTEIN; DIFFERENTIAL EXPRESSION; ENDOGENOUS LECTIN; SODIUM-BUTYRATE; THYROID-TUMORS; MUSCLE LECTIN; CELL-ADHESION; T-CELLS; APOPTOSIS; CANCER;
Keywords:
prostate carcinoma; expression; galectin-l; stroma; progression; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: van den Brule, FA Metastasis Res Lab, Pathol B23,Sart Tilman, B-4000 Liege1, Belgium Metastasis Res Lab Pathol B23,Sart Tilman Liege Belgium 1
Citazione:
F.A. van den Brule et al., "Increased expression of galectin-I in carcinoma-associated stroma predictspoor outcome in prostate carcinoma patients", J PATHOLOGY, 193(1), 2001, pp. 80-87

Abstract

Galectin-1, a member of the beta -galactoside-binding galectin family, is a pleiotropic dimeric protein participating in a variety of normal and pathological processes, including cancer progression. Modulation of the interactions with the basement membrane glycoprotein lamimin and induction of apoptosis in activated T lymphocytes are well-known functions of this galectin,In this study, the expression of galectin-1 was examined in 148 human primary prostate carcinoma samples. Immunohistochemical staining of paraffin sections of prostate tissues revealed that galectin-1 was not detected in normal, PIN (prostatic intraepitheliar neoplasia) or carcinoma cells, but accumulated in the stroma and associated fibroblasts, Galectin-1 expression wassignificantly increased in the tumour-associated stroma compared with the nonneoplastic gland-associated stroma in 21.3% of the cases (Mantel-Haenszel test, p=0.001; Wilcoxon signed rank test, p<0.0001). Increased galectin-1expression in the cancer-associated stroma compared to the normal gland-associated stroma (p=0.03) was identified by multivariate analysis as a strong independent predictor of prostate-specific antigen (PSA) recurrence, justafter the pathological stage (p<0.0001). The association between accumulation of galectin-1 in the stroma of the malignant tissue and aggressiveness of the tumour adds weight to the body of evidence that identifies a role for galectin-1 in the acquisition of the. invasive phenotype, In addition to modulating cancer cell interactions with laminin, galectin-1 accumulated around the cancer cells may act as an immunological shield by inducing activated T-cell apoptosis. This exciting hypothesis warrants further investigation. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:32:52