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Titolo:
Hyperhomocysteinemia is associated with venous thrombosis in patients withshort bowel syndrome
Autore:
Compher, CW; Kinosian, BP; Evans-Stoner, N; Huzinec, J; Buzby, GP;
Indirizzi:
Univ Penn Hlth Syst, Clin Nutr Support Serv, Philadelphia, PA 19104 USA Univ Penn Hlth Syst Philadelphia PA USA 19104 Philadelphia, PA 19104 USA Univ Penn Hlth Syst, Dept Med, Philadelphia, PA 19104 USA Univ Penn Hlth Syst Philadelphia PA USA 19104 Philadelphia, PA 19104 USA Univ Penn Hlth Syst, Penn Home Infus Therapy, Philadelphia, PA 19104 USA Univ Penn Hlth Syst Philadelphia PA USA 19104 Philadelphia, PA 19104 USA Univ Penn Hlth Syst, Dept Surg, Philadelphia, PA 19104 USA Univ Penn Hlth Syst Philadelphia PA USA 19104 Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
fascicolo: 1, volume: 25, anno: 2001,
pagine: 1 - 7
SICI:
0148-6071(200101/02)25:1<1:HIAWVT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; HOMOCYSTEINE CONCENTRATIONS; PARENTERAL-NUTRITION; RISK FACTOR; DEFICIENCY; HYPERHOMOCYST(E)INEMIA; HOMOCYST(E)INE; VITAMIN-B-12; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Compher, CW Univ Penn Hlth Syst, Clin Nutr Support Serv, 12 Penn Tower,3400 Spruce St,Philadelphia, PA 19104 USA Univ Penn Hlth Syst 12 Penn Tower,3400 Spruce St Philadelphia PA USA 19104
Citazione:
C.W. Compher et al., "Hyperhomocysteinemia is associated with venous thrombosis in patients withshort bowel syndrome", J PARENT EN, 25(1), 2001, pp. 1-7

Abstract

Background: Hyperhomocysteinemia is associated with venous thrombosis and vitamin deficiency. Patients with short bowel syndrome have increased risk of venous thrombosis due to central catheters, and of vitamin deficiency due to malabsorption. The current investigation was designed to evaluate the relationship between history of venous thrombosis and current hyperhomocystinemia and vitamin deficiency in patients with short bowel syndrome. Methods: Plasma total homocysteine (tHcy), serum vitamin B-12, folate, B-6, and methylmalonic acid (MMA) were measured. Venous thrombosis was documented by venogram or ultrasound. Results: Ten of 17 patients had venous thromboses, including 17 of 38 observed superior and 12 of 26 inferior veins. Total homocysteine was correlated with number of thromboses. The relative risk of multiple thromboses in the highest tHcy tertile was 3.6-fold that of the lowest tertile. Vitamin B-12 and folate levels were within normal limits, but B-12 deficiency by MMA or tHcy level was apparent in 7 patients. Vitamin-deficient patients had higher tHcy and MMA than those without deficiency. Conclusions: Venous thrombosis in patients with short bowel syndrome is relatedto hyperhomocystinemia, which is also related to vitamin B-12 deficiency, not detected by serum vitamin B-12 concentration. Whether treatment of vitamin deficiencies and associated reduction in tHcy will reduce recurrent venous thrombosis in these patients is not known.

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Documento generato il 28/05/20 alle ore 18:38:31