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Titolo:
Subtle alterations in NMDA-stimulated cyclic GMP levels following lateral fluid percussion brain injury
Autore:
Temple, MD; Delahunty, TM; Hamm, RJ; Phillips, LL; Lyeth, BG; Povlishock, JT;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychol, Richmond, VA 23284 USA Virginia Commonwealth Univ Richmond VA USA 23284 , Richmond, VA 23284 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurosurg, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Anat, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 1, volume: 18, anno: 2001,
pagine: 47 - 55
SICI:
0897-7151(200101)18:1<47:SAINCG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOREBRAIN CHOLINE-ACETYLTRANSFERASE; LONG-TERM POTENTIATION; NITRIC-OXIDE; COGNITIVE IMPAIRMENT; RECEPTOR ANTAGONIST; RAT HIPPOCAMPUS; D-CYCLOSERINE; ACTIVATION; ACID; PERFORMANCE;
Keywords:
cyclic GMP; hippocampus; N-methyl-D-aspartate receptor; radioimmunoassay; rats; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Hamm, RJ Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychol, POB 842018, Richmond, VA 23284 USA Virginia Commonwealth Univ POB 842018 Richmond VA USA 23284 4 USA
Citazione:
M.D. Temple et al., "Subtle alterations in NMDA-stimulated cyclic GMP levels following lateral fluid percussion brain injury", J NEUROTRAU, 18(1), 2001, pp. 47-55

Abstract

This study examined whether NMDA-stimulated cyclic GMP levels were alteredat two different time points following lateral fluid percussion injury. At60 min and 15 days postinjury, the left and right hippocampi were dissected and chopped into mini-prisms. Each hippocampus was divided into five equal parts and incubated with either the phosphodiesterase inhibitor IBMX (3-isobutyl-1-methylxanthine, 500 muM) alone, IBMX and N-methyl-D-aspartic acid(NMDA) OR IBMX, NMDA, and glycine (10 MM), Two concentrations of NMDA wereused: 500 or 1,000 muM, Tissues were then assayed for levels of cyclic GMP, Results indicated that there were no changes in basal levels of cyclic GMP at either postinjury time point. At 60 min postinjury, there were no significant main effects for injury or drug concentration. There was a significant injury x side interaction effect with increased levels of NMDA-stimulated cyclic GMP in the hippocampus ipsilateral to the injury impact and decreased cyclic GMP levels in the contralateral hippocampus. There were no significant alterations in NMDA-stimulated cyclic GMP levels at 15 days postinjury, The data from this study indicated that NMDA-stimulated cyclic GMP accumulation is differentially altered in the hippocampus ipsilateral and contralateral to the site of the injury at 1 h after injury, but is normalized by 15 days postinjury, These findings implicate NMDA-mediated intracellularsignaling processes in the acute excitotoxic response to injury.

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Documento generato il 22/01/20 alle ore 09:17:44