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Titolo:
Mapping cerebral glucose metabolism during spatial learning: Interactions of development and traumatic brain injury
Autore:
Prins, ML; Hovda, DA;
Indirizzi:
Dept Neurobiol, Los Angeles, CA USA Dept Neurobiol Los Angeles CA USADept Neurobiol, Los Angeles, CA USA Dept Surg, Los Angeles, CA USA Dept Surg Los Angeles CA USADept Surg, Los Angeles, CA USA Dept Mol & Med Pharmacol, Los Angeles, CA USA Dept Mol & Med Pharmacol Los Angeles CA USA armacol, Los Angeles, CA USA
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 1, volume: 18, anno: 2001,
pagine: 31 - 46
SICI:
0897-7151(200101)18:1<31:MCGMDS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID-PERCUSSION MODEL; MORRIS WATER-MAZE; RAT-BRAIN; POSTNATAL-DEVELOPMENT; PARIETAL CORTEX; MEMORY; MOTOR; HIPPOCAMPUS; TASK; IMMATURE;
Keywords:
autoradiography; brain injury; 2-deoxy-glucose; development; fluid percussion; Morris water maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Prins, ML Med Coll Virginia, Dept Anat, Sanger Hall,1101 E Marshall St,Box980709, Richmond, VA 23298 USA Med Coll Virginia Sanger Hall,1101 E Marshall St,Box 980709 Richmond VA USA 23298
Citazione:
M.L. Prins e D.A. Hovda, "Mapping cerebral glucose metabolism during spatial learning: Interactions of development and traumatic brain injury", J NEUROTRAU, 18(1), 2001, pp. 31-46

Abstract

Previous studies have demonstrated that, compared to adults, postnatal clay 17 (P17) and P28 rats show remarkable cognitive recovery in the Morris water maze (MWM) following fluid percussion injury (FPI). This observed age-at-trauma effect could result from either younger animals solving the MWM task using noninjured neural circuitry or an inability of adult and P28 brains to activate appropriate neural networks due to trauma-induced neurological dysfunction. To address these possibilities, we compared "activated" brain regions during normal MWM acquisition and following FP injury. To generate "activated" images of the brain while animals were performing the MWM task, qualitative [C-14]2-deoxy-D-glucose was conducted on days 2, 5, and 14 during training in sham and injured adult, P28, and P17 rats. When maturational changes in cerebral glucose metabolism are taken into account, the results suggests similar activity changes in the cerebral cortex and lacunosum moleculare of CA1 during acquisition in all age groups, suggesting that thedevelopmental rates of MWM learning do not correspond to different patterns of activated cerebral metabolism. Injured P17s, showing no latency deficits, revealed activated cerebral metabolic patterns similar to noninjured P17 animals. In P28 and adult cases, animals exhibited cognitive deficits andtheir metabolic studies indicated that the cortical-hippocampal pattern ofactivation was disrupted by marked injury-induced metabolic depression, which primarily affected the ipsilateral hemisphere and lasted for as long as14 days in adult animals.

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Documento generato il 26/01/20 alle ore 01:23:14